Safety Data Sheet - Acetonitrile

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Chemical Name Acetonitrile

Product Form Substance

Catalogue No. AL0077

CAS Number 75-05-8

EC Number 200-835-2

EC Index Number 607-001-00-0

Grade DNA Synthesis Grade

HSN Code 29269000

Molecular Formula CH3CN

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier

Chemical Name Acetonitrile

Catalogue No. AL0077

Product form Substance

CAS Number 75-05-8

EC Number 200-835-2

Grade DNA Synthesis Grade

EC Index Number 607-001-00-0

Chemical Formula CH3CN

HSN Code 29269000

Synonyms Methyl cyanide, Ethanenitrile

Chemical Structure -

1.2 Relevant identified uses of the substance or mixture and uses advised against

Use of the substance/mixture Solvent for DNA synthesis and oligonucleotide purification.

Uses advised against Not specified

1.3 Details of the supplier of the safety data sheet

Company identification Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.

1.4 Emergency Contact Details

Phone / e-Mail Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2

Classification source ECHA C&L Inventory via PubChem CID 6342 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements

2.2 Label elements

Hazard pictograms Flammable, Irritant

Signal word Danger

Hazard statements H225: Highly Flammable liquid and vapor; H302: Harmful if swallowed; H312: Harmful in contact with skin; H319: Causes serious eye irritation; H332: Harmful if inhaled

Precautionary statements P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, P370+P378, P403+P235, P501

2.3 Other hazards

Other hazards May cause respiratory irritation; vapors may cause drowsiness or dizziness.

SECTION 3: Composition/information on ingredients

3.1 Substance

Name Acetonitrile

CAS No. 75-05-8

SECTION 4: First aid measures

4.1 Description of first aid measures

First-aid measures after inhalation If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.

First-aid measures after skin contact If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.

First-aid measures after eye contact If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

First-aid measures after ingestion If this chemical has been swallowed, get medical attention immediately.

4.2 Most important symptoms and effects, both acute and delayed

Symptoms relating to use Headache, dizziness, nausea, irritation of eyes and skin.

4.3 Indication of any immediate medical attention and special treatment needed

General information Treat symptomatically. Show this safety data sheet to the treating physician.

SECTION 5: Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media Water spray, carbon dioxide, dry chemical powder, foam.

Unsuitable extinguishing media Not specified

5.2 Special hazards arising from the substance or mixture

Special procedures Vapors are heavier than air and may travel to a source of ignition and flash back.

5.3 Advice for firefighters

Protection during firefighting Do not enter fire area without proper protective equipment, including respiratory protection.

SECTION 6: Accidental release measures

6.1.1 For non-emergency personnel

Emergency procedures Evacuate area. Remove all sources of ignition. Ventilate area.

6.3 Methods and material for containment and cleaning up

Methods for cleaning up Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible.

6.4 Reference to other sections

Reference Not specified

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Precautions for safe handling Use in a well-ventilated area. Avoid contact with skin and eyes. Keep away from heat and open flames.

Hygiene measures Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions Fireproof. Keep in a well-ventilated room. Separated from acids, bases, strong oxidants and food and feedstuffs. Well closed.

SECTION 8: Exposure controls/personal protection

8.2 Exposure controls

Hand protection Protective gloves (e.g. nitrile rubber)

Eye protection Chemical safety goggles or safety glasses

Skin and body protection Wear suitable protective clothing

Respiratory protection Use appropriate respiratory protection if ventilation is inadequate.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

Physical state Liquid

Colour Colorless

Odour Aromatic odor

Odour threshold Not available

pH value Not applicable

Relative evaporation rate (butylacetate=1) 2.0

Melting point -44 °C

Freezing point -45.7 °C

Boiling point 81.6 °C at 760 mm Hg

Flash point 42 °F (6 °C) (Open Cup)

Auto-ignition temperature 975 °F (524 °C)

Decomposition temperature Not available

Flammability (solid, gas) Flammable liquid

Vapour pressure 88.8 mm Hg at 25 °C

Relative vapour density at 20°C 1.42 (Air = 1)

Density Specific gravity: 0.78745 at 15 °C/4 °C

Solubility In water, >800 g/L at 25 °C

Log Pow -0.34

Viscosity, kinematic 0.36 cSt at 20 °C

Viscosity, dynamic 0.3 mPa·s at 20 °C

Explosive properties Not explosive

Oxidising properties Not oxidizing

Explosive limits 3.0 - 16.0 vol% in air

SECTION 10: Stability and reactivity

10.1 Reactivity

Reactivity Stable under normal conditions. Reacts with strong oxidizing agents.

10.2 Chemical stability

Chemical stability Heat contributes to instability.

10.3 Possibility of hazardous reactions

Possibility of hazardous reactions Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including hydrogen cyanide and nitrogen oxides. Reacts violently with strong oxidants.

10.4 Conditions to avoid

Conditions to avoid Avoid contact with incompatible materials and excessive heat.

10.5 Incompatible materials

Incompatible materials Strong oxidizers, strong acids, bases.

10.6 Hazardous decomposition products

Hazardous decomposition products When heated to decomposition, emits highly toxic fumes of cyanides and nitrogen oxides.

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Rat oral 175 mg/kg; LD50 Rat young oral 200 mg/kg; LD50 Guinea pig oral 140 mg/kg

Skin corrosion/irritation Not classified (based on available data)

Serious eye damage/irritation H319: Causes serious eye irritation

Respiratory or skin sensitisation Not classified (based on available data)

Germ cell mutagenicity Not classified (based on available data)

Carcinogenicity Not classified (based on available data)

Specific target organ toxicity (single exposure) Not classified (based on available data)

Specific target organ toxicity (repeated exposure) Not classified (based on available data)

SECTION 12: Ecological information

12.1 Toxicity

Toxicity information Not specified

12.2 Persistence - degradability

Persistence - degradability Not specified

12.3 Bioaccumulative potential

Bioaccumulative potential Not specified

12.4 Mobility in soil

Mobility in soil Not specified

12.6 Other adverse effects

Environmental precautions Not specified

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Additional Info Dispose of contents/container in accordance with local, regional, national and international regulations.

SECTION 14: Transport information

14.1 UN number

UN-No. (ADR) UN 1648

UN-No. (IMDG) UN 1648

UN-No. (IATA) UN 1648

UN-No. (ADN) UN 1648

UN-No. (RID) UN 1648

14.2 UN proper shipping name

Proper Shipping Name (ADR) Acetonitrile

Proper Shipping Name (IMDG) Acetonitrile

Proper Shipping Name (IATA) Acetonitrile

Proper Shipping Name (ADN) Acetonitrile

Proper Shipping Name (RID) Acetonitrile

14.3 Transport hazard class(es)

Transport hazard class(es) 3

14.4 Packing group

Packing group (ADR) II

Packing group (IMDG) II

Packing group (IATA) II

Packing group (ADN) II

Packing group (RID) II

14.5 Environmental hazards

Dangerous for the environment Not specified

Marine pollutant Not specified

Other information No supplementary information available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

15.1.1 EU-Regulations Not specified

SECTION 16: Other Information

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a guarantee or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.