Safety Data Sheet - Arsenic(III) oxide

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Chemical Name Arsenic(III) oxide

Product Form Substance

Catalogue No. AL0497

CAS Number 1327-53-3

EC Number 215-481-4

EC Index Number 033-001-00-3

Grade 98%

HSN Code 28112920

Molecular Formula As2O3

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier

Chemical Name Arsenic(III) oxide

Catalogue No. AL0497

Product form Substance

CAS Number 1327-53-3

EC Number 215-481-4

Grade 98%

EC Index Number 033-001-00-3

Chemical Formula As2O3

HSN Code 28112920

Synonyms Arsenic trioxide, Arsenous oxide

Chemical Structure -

1.2 Relevant identified uses of the substance or mixture and uses advised against

Use of the substance/mixture Used in analytical chemistry and pharmaceuticals.

Uses advised against Not specified

1.3 Details of the supplier of the safety data sheet

Company identification Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.

1.4 Emergency Contact Details

Phone / e-Mail Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Carcinogenicity - category 1A; Germ cell mutagenicity - category 2; Specific target organ toxicity (repeated exposure) - category 1; Hazardous to the aquatic environment (acute) - category 1; Hazardous to the aquatic environment (chronic) - category 1; Skin corrosion - category 1; Acute toxicity (ingestion) - category 2; Acute toxicity (inhalation) - category 3

Classification source Safe Work Australia HCIS via PubChem CID 14888 - government classification; pictograms and signal word derived from those statements

2.2 Label elements

Hazard pictograms Corrosive, Acute Toxic, Health Hazard, Environmental Hazard

Signal word Danger

Hazard statements H300: Fatal if swallowed; H314: Causes severe skin burns and eye damage; H331: Toxic if inhaled; H341: Suspected of causing genetic defects; H350: May cause cancer; H372: Causes damage to organs through prolonged or repeated exposure; H410: Very toxic to aquatic life with long lasting effects

Precautionary statements P203, P260, P261, P264, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P319, P321, P330, P363, P391, P403+P233, P405, P501

2.3 Other hazards

Other hazards Carcinogenic, may cause reproductive toxicity.

SECTION 3: Composition/information on ingredients

3.1 Substance

Name Arsenic(III) oxide

CAS No. 1327-53-3

SECTION 4: First aid measures

4.1 Description of first aid measures

First-aid measures after inhalation Move to fresh air. Seek medical attention immediately.

First-aid measures after skin contact Wash with soap and water. Seek medical attention if irritation persists.

First-aid measures after eye contact Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Seek medical attention.

First-aid measures after ingestion Do not induce vomiting. Seek medical attention immediately.

4.2 Most important symptoms and effects, both acute and delayed

Symptoms relating to use Nausea, vomiting, abdominal pain, diarrhea, respiratory distress.

4.3 Indication of any immediate medical attention and special treatment needed

General information Treat symptomatically. Show this safety data sheet to the treating physician.

SECTION 5: Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media Water spray, carbon dioxide, dry chemical powder, foam.

Unsuitable extinguishing media Not specified

5.2 Special hazards arising from the substance or mixture

Special procedures Toxic fumes may be released in a fire.

5.3 Advice for firefighters

Protection during firefighting Do not enter fire area without proper protective equipment, including respiratory protection.

SECTION 6: Accidental release measures

6.1.1 For non-emergency personnel

Emergency procedures Evacuate area. Wear appropriate protective equipment. Contain spill.

6.3 Methods and material for containment and cleaning up

Methods for cleaning up Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting.

6.4 Reference to other sections

Reference Not specified

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Precautions for safe handling Use only in a fume hood with appropriate PPE. Avoid contact with skin and eyes.

Hygiene measures Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents and food and feedstuffs. Well closed. Store only in original container. Store in an area without drain or sewer access.

SECTION 8: Exposure controls/personal protection

8.2 Exposure controls

Hand protection Protective gloves (e.g. nitrile rubber)

Eye protection Chemical safety goggles or safety glasses

Skin and body protection Wear suitable protective clothing

Respiratory protection Use appropriate respirator if ventilation is inadequate.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

Physical state Solid

Colour White

Odour Odorless

Odour threshold Not applicable

pH value Not applicable

Relative evaporation rate (butylacetate=1) Not applicable

Melting point 313 °C (claudetite); 274 °C (arsenolite)

Freezing point Not applicable

Boiling point 460 °C

Flash point Not applicable

Auto-ignition temperature Not applicable

Decomposition temperature > 300 °C

Flammability (solid, gas) Not flammable

Vapour pressure 2.47X10-4 mm Hg @ 25 °C

Relative vapour density at 20°C Not applicable

Density 3.865 (cubes); 4.15 (rhombic crystals)

Solubility Soluble in glycerol

Log Pow Not applicable

Viscosity, kinematic Not applicable

Viscosity, dynamic Not applicable

Explosive properties Not explosive

Oxidising properties Not oxidizing

Explosive limits Not applicable

SECTION 10: Stability and reactivity

10.1 Reactivity

Reactivity Stable under normal conditions, but reacts with strong acids and bases.

10.2 Chemical stability

Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Possibility of hazardous reactions The solution is a weak acid. It reacts with reducing agents. This produces very toxic gas (arsine).

10.4 Conditions to avoid

Conditions to avoid Avoid contact with incompatible materials and excessive heat.

10.5 Incompatible materials

Incompatible materials Strong acids, strong bases, and oxidizing agents.

10.6 Hazardous decomposition products

Hazardous decomposition products Not combustible, but if involved in a fire decomposes to produce arsenic fumes.

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity LD50 Rat oral (in food) 145 mg/kg; LD50 Mice (several strains) gavage 26-47 mg/kg; LD50 Rat gavage 15 mg/kg

Skin corrosion/irritation H314: Causes severe skin burns and eye damage

Serious eye damage/irritation Not classified (based on available data)

Respiratory or skin sensitisation Not classified (based on available data)

Germ cell mutagenicity H341: Suspected of causing genetic defects

Carcinogenicity H350: May cause cancer

Specific target organ toxicity (single exposure) Not classified (based on available data)

Specific target organ toxicity (repeated exposure) H372: Causes damage to organs through prolonged or repeated exposure

SECTION 12: Ecological information

12.1 Toxicity

Toxicity information Not specified

12.2 Persistence - degradability

Persistence - degradability Not specified

12.3 Bioaccumulative potential

Bioaccumulative potential Not specified

12.4 Mobility in soil

Mobility in soil Not specified

12.6 Other adverse effects

Environmental precautions Not specified

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Additional Info Dispose of contents/container in accordance with local, regional, national and international regulations.

SECTION 14: Transport information

14.1 UN number

UN-No. (ADR) 1561

UN-No. (IMDG) 1561

UN-No. (IATA) 1561

UN-No. (ADN) 1561

UN-No. (RID) 1561

14.2 UN proper shipping name

Proper Shipping Name (ADR) Arsenic trioxide

Proper Shipping Name (IMDG) Arsenic trioxide

Proper Shipping Name (IATA) Arsenic trioxide

Proper Shipping Name (ADN) Arsenic trioxide

Proper Shipping Name (RID) Arsenic trioxide

14.3 Transport hazard class(es)

Transport hazard class(es) 6.1

14.4 Packing group

Packing group (ADR) II

Packing group (IMDG) II

Packing group (IATA) II

Packing group (ADN) II

Packing group (RID) II

14.5 Environmental hazards

Dangerous for the environment Not specified

Marine pollutant Not specified

Other information No supplementary information available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

15.1.1 EU-Regulations Not specified

SECTION 16: Other Information

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a guarantee or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.