Progesterone
Synonyms: Pregn-4-ene-3,20-dione; 17-Hydroxyprogesterone; 4-Pregnen-3,20-dione
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Chemical Name
Progesterone
Product Form
Substance
Catalogue No.
AL3806
CAS Number
57-83-0
EC Number
200-350-6
EC Index Number
607-003-00-4
Grade
97%
HSN Code
29372300
Molecular Formula
C21H30O2
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Chemical Name
Progesterone
Catalogue No.
AL3806
Product form
Substance
CAS Number
57-83-0
EC Number
200-350-6
Grade
97%
EC Index Number
607-003-00-4
Chemical Formula
C21H30O2
HSN Code
29372300
Synonyms
Pregn-4-ene-3,20-dione; 17-Hydroxyprogesterone; 4-Pregnen-3,20-dione
Chemical Structure
-
1.2 Relevant identified uses of the substance or mixture and uses advised against
Use of the substance/mixture
Used in biochemistry and pharmaceutical applications as a hormone standard.
Uses advised against
Not specified
1.3 Details of the supplier of the safety data sheet
Company identification
Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 Emergency Contact Details
Phone / e-Mail
Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Carc. 2; Repr. 1B; Lact.
Classification source
ECHA C&L Inventory via PubChem CID 5994 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 Label elements
Hazard pictograms
Health Hazard
Signal word
Danger
Hazard statements
H351: Suspected of causing cancer; H360: May damage fertility or the unborn child; H362: May cause harm to breast-fed children
2.3 Other hazards
Other hazards
None identified; handle with care as it is a pharmacologically active compound.
SECTION 3: Composition/information on ingredients
3.1 Substance
Name
Progesterone
CAS No.
57-83-0
SECTION 4: First aid measures
4.1 Description of first aid measures
First-aid measures after inhalation
Move to fresh air. If symptoms persist, seek medical attention.
First-aid measures after skin contact
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
First-aid measures after eye contact
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
First-aid measures after ingestion
Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 Most important symptoms and effects, both acute and delayed
Symptoms relating to use
May cause skin irritation or allergic reactions in sensitive individuals.
4.3 Indication of any immediate medical attention and special treatment needed
General information
Treat symptomatically. Show this safety data sheet to the treating physician.
SECTION 5: Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water spray, carbon dioxide, dry chemical powder, foam.
Unsuitable extinguishing media
Not specified
5.2 Special hazards arising from the substance or mixture
Special procedures
Combustible material; may produce toxic fumes when burned.
5.3 Advice for firefighters
Protection during firefighting
Do not enter fire area without proper protective equipment, including respiratory protection.
SECTION 6: Accidental release measures
6.1.1 For non-emergency personnel
Emergency procedures
Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 Methods and material for containment and cleaning up
Methods for cleaning up
Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 Reference to other sections
Reference
Not specified
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Precautions for safe handling
Avoid contact with skin and eyes. Use gloves and protective eyewear when handling.
Hygiene measures
Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Parenteral progesterone preparations, progesterone capsules, progesterone vaginal inserts, and progesterone vaginal gel should be stored at 15-30 °C.
SECTION 8: Exposure controls/personal protection
8.2 Exposure controls
Hand protection
Protective gloves (e.g. nitrile rubber)
Eye protection
Chemical safety goggles or safety glasses
Skin and body protection
Wear suitable protective clothing
Respiratory protection
Not required under normal conditions; use in well-ventilated areas.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
Physical state
Solid
Colour
White
Odour
Odorless
Odour threshold
Not applicable
pH value
Not applicable
Relative evaporation rate (butylacetate=1)
Not applicable
Melting point
129 °C
Freezing point
Not applicable
Boiling point
330 °C
Flash point
150 °C
Auto-ignition temperature
Not applicable
Decomposition temperature
Not applicable
Flammability (solid, gas)
Combustible solid
Vapour pressure
<0.01 mmHg at 25 °C
Relative vapour density at 20°C
Not applicable
Density
1.166 g/cu cm at 23 °C
Solubility
Sol in alcohol, acetone, dioxane beta-Progesterone
Log Pow
3.87
Viscosity, kinematic
Not applicable
Viscosity, dynamic
Not applicable
Explosive properties
Not explosive
Oxidising properties
Not oxidizing
Explosive limits
Not applicable
SECTION 10: Stability and reactivity
10.1 Reactivity
Reactivity
Stable under normal conditions; avoid strong oxidizing agents.
10.2 Chemical stability
Chemical stability
Progesterone is stable when exposed to air. The drug should be stored in tight, light-resistant containers.
10.3 Possibility of hazardous reactions
Possibility of hazardous reactions
No dangerous reactions known under normal conditions of use.
10.4 Conditions to avoid
Conditions to avoid
Avoid contact with incompatible materials and excessive heat.
10.5 Incompatible materials
Incompatible materials
Strong oxidizing agents.
10.6 Hazardous decomposition products
Hazardous decomposition products
When heated to decomposition, it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 (oral, rat) > 2000 mg/kg; low toxicity.
Skin corrosion/irritation
Not classified (based on available data)
Serious eye damage/irritation
Not classified (based on available data)
Respiratory or skin sensitisation
Not classified (based on available data)
Germ cell mutagenicity
Not classified (based on available data)
Carcinogenicity
H351: Suspected of causing cancer
Specific target organ toxicity (single exposure)
Not classified (based on available data)
Specific target organ toxicity (repeated exposure)
Not classified (based on available data)
SECTION 12: Ecological information
12.1 Toxicity
Toxicity information
Not specified
12.2 Persistence - degradability
Persistence - degradability
Not specified
12.3 Bioaccumulative potential
Bioaccumulative potential
Not specified
12.4 Mobility in soil
Mobility in soil
Not specified
12.6 Other adverse effects
Environmental precautions
Not specified
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Additional Info
Dispose of contents/container in accordance with local, regional, national and international regulations.
SECTION 14: Transport information
14.1 UN number
UN-No. (ADR)
Not classified as dangerous goods.
UN-No. (IMDG)
Not classified as dangerous goods.
UN-No. (IATA)
Not classified as dangerous goods.
UN-No. (ADN)
Not classified as dangerous goods.
UN-No. (RID)
Not classified as dangerous goods.
14.2 UN proper shipping name
Proper Shipping Name (ADR)
Progesterone
Proper Shipping Name (IMDG)
Progesterone
Proper Shipping Name (IATA)
Progesterone
Proper Shipping Name (ADN)
Progesterone
Proper Shipping Name (RID)
Progesterone
14.3 Transport hazard class(es)
Transport hazard class(es)
Not applicable
14.4 Packing group
Packing group (ADR)
Not applicable
Packing group (IMDG)
Not applicable
Packing group (IATA)
Not applicable
Packing group (ADN)
Not applicable
Packing group (RID)
Not applicable
14.5 Environmental hazards
Dangerous for the environment
Not specified
Marine pollutant
Not specified
Other information
No supplementary information available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.1.1 EU-Regulations
Not specified
SECTION 16: Other Information
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a guarantee or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.