Tetrahydrofuran
Synonyms: THF, 1,4-Butyrolactone
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Chemical Name
Tetrahydrofuran
Product Form
Substance
Catalogue No.
AL4493
CAS Number
109-99-9
EC Number
203-726-8
EC Index Number
607-195-00-7
Grade
HPLC & Spectroscopy
HSN Code
29321100
Molecular Formula
C4H8O
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Chemical Name
Tetrahydrofuran
Catalogue No.
AL4493
Product form
Substance
CAS Number
109-99-9
EC Number
203-726-8
Grade
HPLC & Spectroscopy
EC Index Number
607-195-00-7
Chemical Formula
C4H8O
HSN Code
29321100
Synonyms
THF, 1,4-Butyrolactone
Chemical Structure
-
1.2 Relevant identified uses of the substance or mixture and uses advised against
Use of the substance/mixture
Solvent for chromatography and spectroscopy
Uses advised against
Not specified
1.3 Details of the supplier of the safety data sheet
Company identification
Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 Emergency Contact Details
Phone / e-Mail
Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; Carc. 2
Classification source
ECHA C&L Inventory via PubChem CID 8028 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 Label elements
Hazard pictograms
Flammable, Irritant, Health Hazard
Signal word
Danger
Hazard statements
H225: Highly Flammable liquid and vapor; H319: Causes serious eye irritation; H335: May cause respiratory irritation; H351: Suspected of causing cancer
2.3 Other hazards
Other hazards
Forms explosive peroxides upon prolonged exposure to air and light.
SECTION 3: Composition/information on ingredients
3.1 Substance
Name
Tetrahydrofuran
CAS No.
109-99-9
SECTION 4: First aid measures
4.1 Description of first aid measures
First-aid measures after inhalation
If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
First-aid measures after skin contact
If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.
First-aid measures after eye contact
If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
First-aid measures after ingestion
If this chemical has been swallowed, get medical attention immediately.
4.2 Most important symptoms and effects, both acute and delayed
Symptoms relating to use
Headache, dizziness, nausea, respiratory irritation, skin irritation.
4.3 Indication of any immediate medical attention and special treatment needed
General information
Treat symptomatically. Show this safety data sheet to the treating physician.
SECTION 5: Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water spray, carbon dioxide, dry chemical powder, foam.
Unsuitable extinguishing media
Not specified
5.2 Special hazards arising from the substance or mixture
Special procedures
Tetrahydrofuran (THF) is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." A 5% solution of THF in water is flammable.
5.3 Advice for firefighters
Protection during firefighting
Do not enter fire area without proper protective equipment, including respiratory protection.
SECTION 6: Accidental release measures
6.1.1 For non-emergency personnel
Emergency procedures
Evacuate area. Remove all sources of ignition. Ventilate area.
6.3 Methods and material for containment and cleaning up
Methods for cleaning up
Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Do NOT wash away into sewer.
6.4 Reference to other sections
Reference
Not specified
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Precautions for safe handling
Use in a well-ventilated area. Avoid contact with skin and eyes. Keep away from heat and ignition sources.
Hygiene measures
Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Fireproof. Well closed. Keep separated from incompatible materials.
SECTION 8: Exposure controls/personal protection
8.2 Exposure controls
Hand protection
Protective gloves (e.g. nitrile rubber)
Eye protection
Chemical safety goggles or safety glasses
Skin and body protection
Wear suitable protective clothing
Respiratory protection
Use appropriate respiratory protection if ventilation is inadequate.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
Physical state
Liquid
Colour
Colorless
Odour
Ether-like odor
Odour threshold
Not specified
pH value
Not applicable
Relative evaporation rate (butylacetate=1)
>1
Melting point
-108.44 °C
Freezing point
Not specified
Boiling point
65 °C
Flash point
-14 °C
Auto-ignition temperature
321 °C (610 °F)
Decomposition temperature
Not specified
Flammability (solid, gas)
Highly flammable liquid
Vapour pressure
Vapor pressure = 0.06 atm at 0 °C, 0.11 atm at 10 °C, 0.173 atm at 20 °C, 0.26 atm at 30 °C
Relative vapour density at 20°C
2.5 (Air = 1)
Density
0.8833 g/cu cm at 25 °C
Solubility
Miscible with alcohols, ketones, esters, hydrocarbons, and ethers.
Log Pow
0.46
Viscosity, kinematic
0.45 cSt at 20°C
Viscosity, dynamic
Not specified
Explosive properties
Forms explosive peroxides
Oxidising properties
Not oxidizing
Explosive limits
1.8 - 11.8% (v/v) in air
SECTION 10: Stability and reactivity
10.1 Reactivity
Reactivity
Reacts violently with strong oxidizers and can form peroxides upon exposure to air.
10.2 Chemical stability
Chemical stability
Tetrahydrofuran will auto-oxidize in the presence of light & O2 to form resinous products that color water from pink to brown at conc above 100-250 mg/l.
10.3 Possibility of hazardous reactions
Possibility of hazardous reactions
The substance can form explosive peroxides. Reacts violently with strong oxidants, strong bases and some metal halides. This generates fire and explosion hazard.
10.4 Conditions to avoid
Conditions to avoid
Avoid contact with incompatible materials and excessive heat.
10.5 Incompatible materials
Incompatible materials
Strong oxidizing agents, strong acids, and bases.
10.6 Hazardous decomposition products
Hazardous decomposition products
When heated to decomposition it emits acrid smoke & irritating fumes.
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LC50 Rat inhalation 80,975 ppm/1 hr; LC50 Rat inhalation 62,000 ppm/2 hr; LC50 Rat inhalation 18,000-22,000 ppm/4 hr
Skin corrosion/irritation
Not classified (based on available data)
Serious eye damage/irritation
H319: Causes serious eye irritation
Respiratory or skin sensitisation
Not classified (based on available data)
Germ cell mutagenicity
Not classified (based on available data)
Carcinogenicity
H351: Suspected of causing cancer
Specific target organ toxicity (single exposure)
H335: May cause respiratory irritation
Specific target organ toxicity (repeated exposure)
Not classified (based on available data)
SECTION 12: Ecological information
12.1 Toxicity
Toxicity information
Not specified
12.2 Persistence - degradability
Persistence - degradability
Not specified
12.3 Bioaccumulative potential
Bioaccumulative potential
Not specified
12.4 Mobility in soil
Mobility in soil
Not specified
12.6 Other adverse effects
Environmental precautions
Not specified
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Additional Info
Dispose of contents/container in accordance with local, regional, national and international regulations.
SECTION 14: Transport information
14.1 UN number
UN-No. (ADR)
2056
UN-No. (IMDG)
2056
UN-No. (IATA)
2056
UN-No. (ADN)
2056
UN-No. (RID)
2056
14.2 UN proper shipping name
Proper Shipping Name (ADR)
Tetrahydrofuran
Proper Shipping Name (IMDG)
Tetrahydrofuran
Proper Shipping Name (IATA)
Tetrahydrofuran
Proper Shipping Name (ADN)
Tetrahydrofuran
Proper Shipping Name (RID)
Tetrahydrofuran
14.3 Transport hazard class(es)
Transport hazard class(es)
3
14.4 Packing group
Packing group (ADR)
II
Packing group (IMDG)
II
Packing group (IATA)
II
Packing group (ADN)
II
Packing group (RID)
II
14.5 Environmental hazards
Dangerous for the environment
Not specified
Marine pollutant
Not specified
Other information
No supplementary information available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.1.1 EU-Regulations
Not specified
SECTION 16: Other Information
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a guarantee or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.