Trifluoroacetic Acid
Synonyms: TFA, Trifluoroacetic Acid
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Chemical Name
Trifluoroacetic Acid
Product Form
Substance
Catalogue No.
AL4660
CAS Number
76-05-1
EC Number
200-929-3
EC Index Number
607-198-00-6
Grade
98% Extra Pure
HSN Code
29159099
Molecular Formula
C2HF3O2
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Chemical Name
Trifluoroacetic Acid
Catalogue No.
AL4660
Product form
Substance
CAS Number
76-05-1
EC Number
200-929-3
Grade
98% Extra Pure
EC Index Number
607-198-00-6
Chemical Formula
C2HF3O2
HSN Code
29159099
Synonyms
TFA, Trifluoroacetic Acid
Chemical Structure
-
1.2 Relevant identified uses of the substance or mixture and uses advised against
Use of the substance/mixture
Used in peptide synthesis and HPLC mobile phases.
Uses advised against
Not specified
1.3 Details of the supplier of the safety data sheet
Company identification
Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 Emergency Contact Details
Phone / e-Mail
Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin Corr. 1A; Acute Tox. 4; Aquatic Chronic 3
Classification source
ECHA C&L Inventory via PubChem CID 6422 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 Label elements
Hazard pictograms
Corrosive, Irritant
Signal word
Danger
Hazard statements
H314: Causes severe skin burns and eye damage; H332: Harmful if inhaled; H412: Harmful to aquatic life with long lasting effects
2.3 Other hazards
Other hazards
Corrosive to metals; may cause severe skin burns and eye damage.
SECTION 3: Composition/information on ingredients
3.1 Substance
Name
Trifluoroacetic Acid
CAS No.
76-05-1
SECTION 4: First aid measures
4.1 Description of first aid measures
First-aid measures after inhalation
Remove to fresh air. If breathing is difficult, give oxygen. Seek medical attention immediately.
First-aid measures after skin contact
Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Seek medical attention.
First-aid measures after eye contact
Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention immediately.
First-aid measures after ingestion
Do not induce vomiting. Rinse mouth. Seek medical attention immediately.
4.2 Most important symptoms and effects, both acute and delayed
Symptoms relating to use
Severe burns, respiratory distress, and irritation of the skin and eyes.
4.3 Indication of any immediate medical attention and special treatment needed
General information
Treat symptomatically. Show this safety data sheet to the treating physician.
SECTION 5: Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water spray, carbon dioxide, dry chemical powder, foam.
Unsuitable extinguishing media
Not specified
5.2 Special hazards arising from the substance or mixture
Special procedures
The vapour is heavier than air.
5.3 Advice for firefighters
Protection during firefighting
Do not enter fire area without proper protective equipment, including respiratory protection.
SECTION 6: Accidental release measures
6.1.1 For non-emergency personnel
Emergency procedures
Evacuate area. Wear appropriate protective equipment. Contain spill and absorb with inert material.
6.3 Methods and material for containment and cleaning up
Methods for cleaning up
Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable plastic containers. Absorb remaining liquid in sand or inert absorbent.
6.4 Reference to other sections
Reference
Not specified
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Precautions for safe handling
Use in a fume hood with appropriate PPE including gloves and goggles. Avoid contact with skin and eyes.
Hygiene measures
Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Separated from strong bases, metals, oxidants and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access.
SECTION 8: Exposure controls/personal protection
8.2 Exposure controls
Hand protection
Protective gloves (e.g. nitrile rubber)
Eye protection
Chemical safety goggles or safety glasses
Skin and body protection
Wear suitable protective clothing
Respiratory protection
Use appropriate respiratory protection if ventilation is inadequate.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
Physical state
Liquid
Colour
Colorless
Odour
Sharp biting odor
Odour threshold
Not specified
pH value
Not specified
Relative evaporation rate (butylacetate=1)
Not specified
Melting point
-15.4 °C
Freezing point
Not specified
Boiling point
72.4 °C
Flash point
Not applicable
Auto-ignition temperature
Not applicable
Decomposition temperature
Not specified
Flammability (solid, gas)
Not flammable
Vapour pressure
Vapor pressure, kPa at 20 °C: 11
Relative vapour density at 20°C
Relative vapor density (air = 1): 3.9
Density
1.531 at 20 °C
Solubility
Miscible with ether, acetone, ethanol, benzene, carbon tetrachloride, hexane.
Log Pow
-2.1
Viscosity, kinematic
Not specified
Viscosity, dynamic
Not specified
Explosive properties
Not explosive
Oxidising properties
Not oxidizing
Explosive limits
Not applicable
SECTION 10: Stability and reactivity
10.1 Reactivity
Reactivity
Reacts violently with strong bases and oxidizing agents.
10.2 Chemical stability
Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Possibility of hazardous reactions
Decomposes on contact with hot surfaces or flames. This produces toxic fumes. The substance is a medium strong acid.
10.4 Conditions to avoid
Conditions to avoid
Avoid contact with incompatible materials and excessive heat.
10.5 Incompatible materials
Incompatible materials
Strong bases, oxidizing agents, and metals.
10.6 Hazardous decomposition products
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of hydrogen fluorides.
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Rat oral rat 200 mg/kg; LC50 Rat inhalation rat 10 g/cu m (duration unspecified); LC50 Mouse inhalation 13500 mg/cu m (Duration of exposure unspecified)
Skin corrosion/irritation
H314: Causes severe skin burns and eye damage
Serious eye damage/irritation
Not classified (based on available data)
Respiratory or skin sensitisation
Not classified (based on available data)
Germ cell mutagenicity
Not classified (based on available data)
Carcinogenicity
Not classified (based on available data)
Specific target organ toxicity (single exposure)
Not classified (based on available data)
Specific target organ toxicity (repeated exposure)
Not classified (based on available data)
SECTION 12: Ecological information
12.1 Toxicity
Toxicity information
Not specified
12.2 Persistence - degradability
Persistence - degradability
Not specified
12.3 Bioaccumulative potential
Bioaccumulative potential
Not specified
12.4 Mobility in soil
Mobility in soil
Not specified
12.6 Other adverse effects
Environmental precautions
Not specified
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Additional Info
Dispose of contents/container in accordance with local, regional, national and international regulations.
SECTION 14: Transport information
14.1 UN number
UN-No. (ADR)
UN 2699
UN-No. (IMDG)
UN 2699
UN-No. (IATA)
UN 2699
UN-No. (ADN)
UN 2699
UN-No. (RID)
UN 2699
14.2 UN proper shipping name
Proper Shipping Name (ADR)
Trifluoroacetic Acid
Proper Shipping Name (IMDG)
Trifluoroacetic Acid
Proper Shipping Name (IATA)
Trifluoroacetic Acid
Proper Shipping Name (ADN)
Trifluoroacetic Acid
Proper Shipping Name (RID)
Trifluoroacetic Acid
14.3 Transport hazard class(es)
Transport hazard class(es)
8
14.4 Packing group
Packing group (ADR)
I
Packing group (IMDG)
I
Packing group (IATA)
I
Packing group (ADN)
I
Packing group (RID)
I
14.5 Environmental hazards
Dangerous for the environment
Not specified
Marine pollutant
Not specified
Other information
No supplementary information available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.1.1 EU-Regulations
Not specified
SECTION 16: Other Information
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a guarantee or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.