Trimethoprim
Synonyms: TMP, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Chemical Name
Trimethoprim
Product Form
Substance
Catalogue No.
AL4669A
CAS Number
738-70-5
EC Number
212-006-2
EC Index Number
-
Grade
Extra Pure
HSN Code
29335920
Molecular Formula
C14H18N4O3
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Chemical Name
Trimethoprim
Catalogue No.
AL4669A
Product form
Substance
CAS Number
738-70-5
EC Number
212-006-2
Grade
Extra Pure
EC Index Number
Not applicable
Chemical Formula
C14H18N4O3
HSN Code
29335920
Synonyms
TMP, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
Chemical Structure
-
1.2 Relevant identified uses of the substance or mixture and uses advised against
Use of the substance/mixture
Antibiotic, reference standard
Uses advised against
Not specified
1.3 Details of the supplier of the safety data sheet
Company identification
Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 Emergency Contact Details
Phone / e-Mail
Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute Tox. 4
Classification source
ECHA C&L Inventory via PubChem CID 5578 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 Label elements
Hazard pictograms
Irritant
Signal word
Warning
Hazard statements
H302: Harmful if swallowed
2.3 Other hazards
Other hazards
None identified
SECTION 3: Composition/information on ingredients
3.1 Substance
Name
Trimethoprim
CAS No.
738-70-5
SECTION 4: First aid measures
4.1 Description of first aid measures
First-aid measures after inhalation
Move to fresh air. If symptoms persist, seek medical attention.
First-aid measures after skin contact
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
First-aid measures after eye contact
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
First-aid measures after ingestion
Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 Most important symptoms and effects, both acute and delayed
Symptoms relating to use
Nausea, vomiting, skin rash, and allergic reactions in sensitive individuals.
4.3 Indication of any immediate medical attention and special treatment needed
General information
Treat symptomatically. Show this safety data sheet to the treating physician.
SECTION 5: Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Water spray, carbon dioxide, dry chemical powder, foam.
Unsuitable extinguishing media
Not specified
5.2 Special hazards arising from the substance or mixture
Special procedures
May emit toxic fumes under fire conditions.
5.3 Advice for firefighters
Protection during firefighting
Do not enter fire area without proper protective equipment, including respiratory protection.
SECTION 6: Accidental release measures
6.1.1 For non-emergency personnel
Emergency procedures
Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 Methods and material for containment and cleaning up
Methods for cleaning up
Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 Reference to other sections
Reference
Not specified
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Precautions for safe handling
Handle with gloves and avoid contact with skin and eyes. Use in a well-ventilated area.
Hygiene measures
Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Trimethoprim tablets should be stored in tight, light-resistant containers at 15-30 °C in a dry place.
SECTION 8: Exposure controls/personal protection
8.2 Exposure controls
Hand protection
Protective gloves (e.g. nitrile rubber)
Eye protection
Chemical safety goggles or safety glasses
Skin and body protection
Wear suitable protective clothing
Respiratory protection
Not required under normal conditions; use in a well-ventilated area.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
Physical state
Solid
Colour
White to pale yellow
Odour
Odorless
Odour threshold
Not applicable
pH value
Not applicable
Relative evaporation rate (butylacetate=1)
Not applicable
Melting point
390 to 397 °F
Freezing point
Not applicable
Boiling point
360 °C
Flash point
Not applicable
Auto-ignition temperature
Not applicable
Decomposition temperature
Not applicable
Flammability (solid, gas)
Not flammable
Vapour pressure
Not applicable
Relative vapour density at 20°C
Not applicable
Density
1.3 g/cm³
Solubility
Very slightly soluble in water and slightly soluble in alcohol.
Log Pow
0.91
Viscosity, kinematic
Not applicable
Viscosity, dynamic
Not applicable
Explosive properties
Not explosive
Oxidising properties
Not oxidising
Explosive limits
Not applicable
SECTION 10: Stability and reactivity
10.1 Reactivity
Reactivity
Stable under normal conditions.
10.2 Chemical stability
Chemical stability
The solubility of trimethoprim in aqueous solns is partially dependent on the pH of the soln. Trimethoprim is a weak base, & its solubility is lower in solns with a more alkaline pH.
10.3 Possibility of hazardous reactions
Possibility of hazardous reactions
No dangerous reactions known under normal conditions of use.
10.4 Conditions to avoid
Conditions to avoid
Avoid contact with incompatible materials and excessive heat.
10.5 Incompatible materials
Incompatible materials
Strong oxidizing agents.
10.6 Hazardous decomposition products
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of nitrogen oxide.
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Rat oral 200 mg/kg; LD50 Mice oral 7000 mg/kg; LD50 Mouse oral 3960 mg/kg
Skin corrosion/irritation
Not classified (based on available data)
Serious eye damage/irritation
Not classified (based on available data)
Respiratory or skin sensitisation
Not classified (based on available data)
Germ cell mutagenicity
Not classified (based on available data)
Carcinogenicity
Not classified (based on available data)
Specific target organ toxicity (single exposure)
Not classified (based on available data)
Specific target organ toxicity (repeated exposure)
Not classified (based on available data)
SECTION 12: Ecological information
12.1 Toxicity
Toxicity information
Not specified
12.2 Persistence - degradability
Persistence - degradability
Not specified
12.3 Bioaccumulative potential
Bioaccumulative potential
Not specified
12.4 Mobility in soil
Mobility in soil
Not specified
12.6 Other adverse effects
Environmental precautions
Not specified
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Additional Info
Dispose of contents/container in accordance with local, regional, national and international regulations.
SECTION 14: Transport information
14.1 UN number
UN-No. (ADR)
Not assigned
UN-No. (IMDG)
Not assigned
UN-No. (IATA)
Not assigned
UN-No. (ADN)
Not assigned
UN-No. (RID)
Not assigned
14.2 UN proper shipping name
Proper Shipping Name (ADR)
Not classified as dangerous goods
Proper Shipping Name (IMDG)
Not classified as dangerous goods
Proper Shipping Name (IATA)
Not classified as dangerous goods
Proper Shipping Name (ADN)
Not classified as dangerous goods
Proper Shipping Name (RID)
Not classified as dangerous goods
14.3 Transport hazard class(es)
Transport hazard class(es)
Not applicable
14.4 Packing group
Packing group (ADR)
Not applicable
Packing group (IMDG)
Not applicable
Packing group (IATA)
Not applicable
Packing group (ADN)
Not applicable
Packing group (RID)
Not applicable
14.5 Environmental hazards
Dangerous for the environment
Not specified
Marine pollutant
Not specified
Other information
No supplementary information available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.1.1 EU-Regulations
Not specified
SECTION 16: Other Information
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a guarantee or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.