Acetonitrile
- CAS Number
- 75-05-8
- HSN Code
- 29269000
- Molecular Formula
- CH3CN
- Catalogue Number
- AL0072
- Purity
- 99.9%
- Molecular Weight
- 41.05 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Acetonitrile is a nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group. It has a role as a polar aprotic solvent and an EC 3.5.1.4 (amidase) inhibitor.
Also known as Methyl cyanide, Cyanomethane.
- Catalogue No.
- AL0072
- CAS Number
- 75-05-8
- Molecular Formula
- CH3CN
- Molecular Weight
- 41.05 g/mol
- HSN Code
- 29269000
- Grade
- HPLC Gradient
- Product Form
- Substance
Melting point: -44 °C; Boiling point: 81.6 °C at 760 mm Hg; Flash point: 42 °F (6 °C) (Open Cup); Density: Specific gravity: 0.78745 at 15 °C/4 °C; Solubility: In water, >800 g/L at 25 °C.
- Appearance
- Colorless, limpid liquid
- Shelf Life
- 12 months
- Packaging
- Available in: 1 Lt glass bottle with tin cap, 2.5 Lt glass bottle with tin cap
- Storage
- Fireproof. Keep in a well-ventilated room. Separated from acids, bases, strong oxidants and food and feedstuffs. Well closed.
1.1 — Product identifier
- Chemical Name
- Acetonitrile
- Catalogue No.
- AL0072
- Product form
- Substance
- CAS Number
- 75-05-8
- EC Number
- 200-835-2
- Grade
- HPLC Gradient
- EC Index Number
- 607-001-00-0
- Chemical Formula
- CH3CN
- HSN Code
- 29269000
- Synonyms
- Methyl cyanide, Cyanomethane
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Solvent for HPLC and other analytical techniques.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2
- Classification source
- ECHA C&L Inventory via PubChem CID 6342 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Flammable, Irritant
- Signal word
- Danger
- Hazard statements
- H225: Highly Flammable liquid and vapor; H302: Harmful if swallowed; H312: Harmful in contact with skin; H319: Causes serious eye irritation; H332: Harmful if inhaled
- Precautionary statements
- P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, P370+P378, P403+P235, P501
2.3 — Other hazards
- Other hazards
- May cause respiratory irritation and central nervous system effects.
3.1 — Substance
- Name
- Acetonitrile
- CAS No.
- 75-05-8
4.1 — Description of first aid measures
- First-aid measures after inhalation
- If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
- First-aid measures after skin contact
- If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.
- First-aid measures after eye contact
- If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
- First-aid measures after ingestion
- If this chemical has been swallowed, get medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, and respiratory distress.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Vapors are heavier than air and may travel to a source of ignition and flash back.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Remove all sources of ignition. Ventilate area and contain spill.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood. Avoid contact with skin and eyes. Use appropriate personal protective equipment.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Fireproof. Keep in a well-ventilated room. Separated from acids, bases, strong oxidants and food and feedstuffs. Well closed.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Aromatic odor
- Odour threshold
- Not established
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- 2.0
- Melting point
- -44 °C
- Freezing point
- -45.7 °C
- Boiling point
- 81.6 °C at 760 mm Hg
- Flash point
- 42 °F (6 °C) (Open Cup)
- Auto-ignition temperature
- 975 °F (524 °C)
- Decomposition temperature
- Not established
- Flammability (solid, gas)
- Flammable liquid
- Vapour pressure
- 88.8 mm Hg at 25 °C
- Relative vapour density at 20°C
- 1.42 (Air = 1)
- Density
- Specific gravity: 0.78745 at 15 °C/4 °C
- Solubility
- In water, >800 g/L at 25 °C
- Log Pow
- -0.34
- Viscosity, kinematic
- 0.36 cSt at 20 °C
- Viscosity, dynamic
- 0.36 mPa·s at 20 °C
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Lower: 5.7% vol, Upper: 40% vol
10.1 — Reactivity
- Reactivity
- Stable under normal conditions. Reacts with strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Heat contributes to instability.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including hydrogen cyanide and nitrogen oxides. Reacts violently with strong oxidants.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizers, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition, emits highly toxic fumes of cyanides and nitrogen oxides.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Rat oral 175 mg/kg; LD50 Rat young oral 200 mg/kg; LD50 Guinea pig oral 140 mg/kg
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- H319: Causes serious eye irritation
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 1648
- UN-No. (IMDG)
- UN 1648
- UN-No. (IATA)
- UN 1648
- UN-No. (ADN)
- UN 1648
- UN-No. (RID)
- UN 1648
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Acetonitrile
- Proper Shipping Name (IMDG)
- Acetonitrile
- Proper Shipping Name (IATA)
- Acetonitrile
- Proper Shipping Name (ADN)
- Acetonitrile
- Proper Shipping Name (RID)
- Acetonitrile
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used for gradient-elution HPLC methods where solvent purity directly affects detector baseline stability. Commonly utilized in pharmaceutical and biochemical analysis.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1671A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 41.05 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99.9% min | 99.95% |
| Water Content | <0.1% | 0.05% |
| UV Absorbance | <0.005 at 210 nm | 0.002 at 210 nm |
| Related Substances | <0.1% | 0.03% |
| Density | 0.786 g/mL | 0.786 g/mL |
The above product is expected to comply with HPLC Gradient grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| HPLC Gradient | 99.9% | m.p. -44 °C; b.p. 81.6 °C at 760 mm Hg | <0.1% | <0.01% | <0.1% | In water, >800 g/L at 25 °C |
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