Dapsone
- CAS Number
- 80-08-0
- HSN Code
- 29309099
- Molecular Formula
- C12H12N2O2S
- Catalogue Number
- AL1621
- Purity
- ≥ 97%
- Molecular Weight
- 248.30 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Dapsone is a sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
Also known as 4,4'-Diaminodiphenyl sulfone.
- Catalogue No.
- AL1621
- CAS Number
- 80-08-0
- Molecular Formula
- C12H12N2O2S
- Molecular Weight
- 248.30 g/mol
- HSN Code
- 29309099
- Grade
- 97% Extra Pure
- Product Form
- Substance
Melting point: 175-176 °C (also a higher melting form, MP 180.5 °C); Flash point: greater than 320 °F; Density: 1.33 at 77 °F - Denser than water; will sink; Solubility: In water, 380 mg/L at 37 °C.
- Appearance
- Crystals from 95% ethanol
- Shelf Life
- 2 years
- Packaging
- Available in: 25 gm glass bottle, 100 gm glass bottle
- Storage
- Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
1.1 — Product identifier
- Chemical Name
- Dapsone
- Catalogue No.
- AL1621
- Product form
- Substance
- CAS Number
- 80-08-0
- EC Number
- 201-248-4
- Grade
- 97% Extra Pure
- EC Index Number
- 612-007-00-4
- Chemical Formula
- C12H12N2O2S
- HSN Code
- 29309099
- Synonyms
- 4,4'-Diaminodiphenyl sulfone
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Antibiotic and anti-inflammatory agent
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Acute Tox. 4
- Classification source
- ECHA C&L Inventory via PubChem CID 2955 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Irritant
- Signal word
- Warning
- Hazard statements
- H302: Harmful if swallowed
2.3 — Other hazards
- Other hazards
- May cause skin and eye irritation; potential for sensitization.
3.1 — Substance
- Name
- Dapsone
- CAS No.
- 80-08-0
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
- First-aid measures after eye contact
- First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, skin rash.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use gloves and protective eyewear. Avoid inhalation and contact with skin.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
8.2 — Exposure controls
- Hand protection
- Handle with gloves.
- Eye protection
- Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use in a well-ventilated area; use respiratory protection if necessary.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to off-white
- Odour
- Odorless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 175-176 °C (also a higher melting form, MP 180.5 °C)
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- greater than 320 °F
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Negligible
- Relative vapour density at 20°C
- 8.3 (Air = 1)
- Density
- 1.33 at 77 °F - Denser than water; will sink
- Solubility
- In water, 380 mg/L at 37 °C
- Log Pow
- 0.97
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition it emits very toxic fumes of nitrogen and sulfur oxides.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Rat oral 1000 mg/kg; LD50 Mouse oral 375 mg/kg; LD50 Rat ip 196 mg/kg
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- 3077
- UN-No. (IMDG)
- 3077
- UN-No. (IATA)
- 3077
- UN-No. (ADN)
- 3077
- UN-No. (RID)
- 3077
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (IMDG)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (IATA)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (ADN)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (RID)
- Environmentally hazardous substance, solid, n.o.s.
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 9
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used as a reference standard in pharmaceutical quality control for antileprotic/dermatological drug research.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL02160
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 248.30 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 97% | 98.5% |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
| Solubility | Practically insoluble in water | Practically insoluble in water |
The above product is expected to comply with 97% Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 97% Extra Pure | ≥ 97% | m.p. 175-176 °C (also a higher melting form, MP 180.5 °C) | ≤ 0.5% | ≤ 0.1% | None detected | In water, 380 mg/L at 37 °C |
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