Dithiothreitol
- CAS Number
- 3483-12-3
- HSN Code
- 29309099
- Molecular Formula
- C4H10O2S2
- Catalogue Number
- AL1945
- Purity
- ≥ 99%
- Molecular Weight
- 154.24 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
L-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a D-1,4-dithiothreitol.
Also known as Cleland's reagent.
- Catalogue No.
- AL1945
- CAS Number
- 3483-12-3
- Molecular Formula
- C4H10O2S2
- Molecular Weight
- 154.24 g/mol
- HSN Code
- 29309099
- Grade
- 99%
- Product Form
- Substance
Melting point: 42-43 °C; Boiling point: BP: 115-116 °C at 1 mm Hg; Solubility: Freely soluble in water.
- Appearance
- Needles from ether
- Shelf Life
- Stable under recommended storage conditions
- Packaging
- Available in: 1 gm glass bottle, 5 gm glass bottle, 25 gm glass bottle
- Storage
- Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Keep in a dry place.
1.1 — Product identifier
- Chemical Name
- Dithiothreitol
- Catalogue No.
- AL1945
- Product form
- Substance
- CAS Number
- 3483-12-3
- EC Number
- 222-468-7
- Grade
- 99%
- EC Index Number
- Not specified
- Chemical Formula
- C4H10O2S2
- HSN Code
- 29309099
- Synonyms
- Cleland's reagent
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Reducing agent in biochemical applications
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2; STOT SE 3
- Classification source
- ECHA C&L Inventory via PubChem CID 439196 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Irritant
- Signal word
- Warning
- Hazard statements
- H302: Harmful if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation; H335: May cause respiratory irritation
2.3 — Other hazards
- Other hazards
- Mild irritant; gloves recommended during handling.
3.1 — Substance
- Name
- Dithiothreitol
- CAS No.
- 3483-12-3
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of eyes, skin, and respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Clean up spills immediately and dispose of waste properly.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2 - 8 °C. Keep in a dry place.
8.2 — Exposure controls
- Hand protection
- Handle with gloves.
- Eye protection
- Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
- Skin and body protection
- Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to off-white
- Odour
- Characteristic
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- 42-43 °C
- Freezing point
- Not specified
- Boiling point
- BP: 115-116 °C at 1 mm Hg
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable under normal conditions
- Vapour pressure
- Not specified
- Relative vapour density at 20°C
- Not specified
- Density
- 1.36 g/cm³
- Solubility
- Freely soluble in water
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; incompatible with strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Chemical stability: May decompose on exposure to moist air or water. Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Hazardous decomposition products formed under fire conditions: Carbon oxides, sulfur oxides.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Mice im 108 mg/kg; LD50 Mice ip 154 mg/kg
- Skin corrosion/irritation
- H315: Causes skin irritation
- Serious eye damage/irritation
- H319: Causes serious eye irritation
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- H335: May cause respiratory irritation
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3335
- UN-No. (IMDG)
- UN 3335
- UN-No. (IATA)
- UN 3335
- UN-No. (ADN)
- UN 3335
- UN-No. (RID)
- UN 3335
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Dithiothreitol
- Proper Shipping Name (IMDG)
- Dithiothreitol
- Proper Shipping Name (IATA)
- Dithiothreitol
- Proper Shipping Name (ADN)
- Dithiothreitol
- Proper Shipping Name (RID)
- Dithiothreitol
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 9
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
DTT is primarily used as a reducing agent in biochemical applications, particularly for maintaining free thiol groups in proteins during SDS-PAGE and in various protein purification processes.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2251D
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 154.24 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay (Purity) | ≥ 99% | 99.5% |
| Melting Point | 18-20 °C | 19 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
| Solubility | Soluble in water | Fully soluble in water at room temperature. |
The above product is expected to comply with 99% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% | ≥ 99% | m.p. 42-43 °C; b.p. BP: 115-116 °C at 1 mm Hg | ≤ 0.5% | ≤ 0.1% | None detected by HPLC | Freely soluble in water |
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