Hexamethylphosphoric acid triamide
- CAS Number
- 680-31-9
- HSN Code
- 29319090
- Molecular Formula
- [(CH3)2N]3PO
- Catalogue Number
- AL2392
- Purity
- ≥ 98%
- Molecular Weight
- 179.20 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Hexamethylphosphoric triamide is a phosphoramide. It has a role as a mutagen and an insect sterilant.
Also known as HMPA.
- Catalogue No.
- AL2392
- CAS Number
- 680-31-9
- Molecular Formula
- [(CH3)2N]3PO
- Molecular Weight
- 179.20 g/mol
- HSN Code
- 29319090
- Grade
- 98%
- Product Form
- Substance
Melting point: FP: 5-7 °C; Boiling point: 233 °C @ 760 MM HG; Flash point: 105 °C; Density: 1.03 @ 20 °C; Solubility: Solubility in water: very good.
- Appearance
- Clear, colorless liquid [Note: A solid below 43 degrees F]
- Shelf Life
- -
- Packaging
- Available in: 100 ml glass bottle, 500 ml glass bottle
- Storage
- Ventilation along the floor. Separated from acids and oxidants.
1.1 — Product identifier
- Chemical Name
- Hexamethylphosphoric acid triamide
- Catalogue No.
- AL2392
- Product form
- Substance
- CAS Number
- 680-31-9
- EC Number
- 211-653-8
- Grade
- 98%
- EC Index Number
- Not specified
- Chemical Formula
- [(CH3)2N]3PO
- HSN Code
- 29319090
- Synonyms
- HMPA
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used as a dipolar aprotic solvent in organic synthesis.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Muta. 1B; Carc. 1B
- Classification source
- ECHA C&L Inventory via PubChem CID 12679 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Health Hazard
- Signal word
- Danger
- Hazard statements
- H340: May cause genetic defects; H350: May cause cancer
- Precautionary statements
- P203, P280, P318, P405, P501
2.3 — Other hazards
- Other hazards
- Carcinogenic; handle with care.
3.1 — Substance
- Name
- Hexamethylphosphoric acid triamide
- CAS No.
- 680-31-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
- First-aid measures after skin contact
- If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.
- First-aid measures after eye contact
- If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
- First-aid measures after ingestion
- If this chemical has been swallowed, get medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of skin, eyes, and respiratory tract; potential carcinogenic effects.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes in a fire. Use appropriate fire-fighting measures.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate PPE. Contain spill and absorb with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate PPE. Avoid contact with skin and eyes.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Ventilation along the floor. Separated from acids and oxidants.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Aromatic or mild, amine-like odor.
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- FP: 5-7 °C
- Freezing point
- Not specified
- Boiling point
- 233 °C @ 760 MM HG
- Flash point
- 105 °C
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- 0.07 mmHg at 77 °F
- Relative vapour density at 20°C
- 6.18 (Air= 1)
- Density
- 1.03 @ 20 °C
- Solubility
- Solubility in water: very good
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; incompatible with strong oxidizers.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes on heating and on burning. Reacts with acids and oxidants. This produces toxic fumes including phosphorus oxides and nitrogen oxides.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition it emits very toxic fume of phosphine, phosphorus oxides and nitrogen oxides.
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled or absorbed through skin.
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- H340: May cause genetic defects
- Carcinogenicity
- H350: May cause cancer
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3267
- UN-No. (IMDG)
- UN 3267
- UN-No. (IATA)
- UN 3267
- UN-No. (ADN)
- UN 3267
- UN-No. (RID)
- UN 3267
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Hexamethylphosphoric acid triamide
- Proper Shipping Name (IMDG)
- Hexamethylphosphoric acid triamide
- Proper Shipping Name (IATA)
- Hexamethylphosphoric acid triamide
- Proper Shipping Name (ADN)
- Hexamethylphosphoric acid triamide
- Proper Shipping Name (RID)
- Hexamethylphosphoric acid triamide
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used as a strongly coordinating dipolar aprotic co-solvent in organolithium and organometallic reactions, with strict exposure controls.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2326C
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 179.20 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | A Clear colourless to pale yellow liquid. | A clear pale yellow liquid. |
| Assay (GC) | 98 % min | 99.31% |
| Density (d4 20) | 1.022 – 1.025 g | 1.024g |
| Refractive Index(nD 20) | 1.458 – 1.460 | 1.460 |
The above product complies with LR grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | m.p. FP: 5-7 °C; b.p. 233 °C @ 760 MM HG | ≤ 0.5% | ≤ 0.1% | None detected | Solubility in water: very good |
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