Isobutyl chloroformate
- CAS Number
- 543-27-1
- HSN Code
- 29159020
- Molecular Formula
- C5H9ClO2
- Catalogue Number
- AL0976
- Purity
- ≥ 98%
- Molecular Weight
- 136.58 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Isobutyl chloroformate appears as a colorless to light-colored liquid. Insoluble in water and denser than water.
Also known as Isobutyl chloroformate.
- Catalogue No.
- AL0976
- CAS Number
- 543-27-1
- Molecular Formula
- C5H9ClO2
- Molecular Weight
- 136.58 g/mol
- HSN Code
- 29159020
- Grade
- For Synthesis
- Product Form
- Substance
Boiling point: 129 °C; Flash point: 27 °C c.c; Density: 1.04 g/cm³; Solubility: Solubility in water: reaction.
- Appearance
- Colourless liquid with pungent odour
- Shelf Life
- 12 months
- Packaging
- Available in: 100 ml glass bottle, 500 ml glass bottle
- Storage
- Fireproof. Dry. Well closed. Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.
1.1 — Product identifier
- Chemical Name
- Isobutyl chloroformate
- Catalogue No.
- AL0976
- Product form
- Substance
- CAS Number
- 543-27-1
- EC Number
- 208-840-1
- Grade
- For Synthesis
- EC Index Number
- 607-007-00-5
- Chemical Formula
- C5H9ClO2
- HSN Code
- 29159020
- Synonyms
- Isobutyl chloroformate
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Reagent for peptide coupling and ester synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Flam. Liq. 3; Met. Corr. 1; Acute Tox. 4; Skin Corr. 1B; Eye Dam. 1; Acute Tox. 3; STOT SE 3
- Classification source
- ECHA C&L Inventory via PubChem CID 62365 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Flammable, Corrosive, Acute Toxic
- Signal word
- Danger
- Hazard statements
- H226: Flammable liquid and vapor; H290: May be corrosive to metals; H302: Harmful if swallowed; H314: Causes severe skin burns and eye damage; H318: Causes serious eye damage; H331: Toxic if inhaled; H335: May cause respiratory irritation
- Precautionary statements
- P210, P233, P234, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P363, P370+P378, P390, P403+P233, P403+P235, P405, P406, P501
2.3 — Other hazards
- Other hazards
- Corrosive to metals
3.1 — Substance
- Name
- Isobutyl chloroformate
- CAS No.
- 543-27-1
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If breathing is difficult, give oxygen. Seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. Remove contaminated clothing. Seek medical attention if irritation persists.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Toxic if inhaled, skin contact may cause burns, eye contact may cause severe irritation.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Flammable liquid; may produce toxic fumes in a fire.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Wear appropriate protective equipment. Contain and absorb spill with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable dry plastic containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate PPE including gloves and goggles.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Fireproof. Dry. Well closed. Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Pungent
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- Not applicable
- Freezing point
- Not applicable
- Boiling point
- 129 °C
- Flash point
- 27 °C c.c.
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Flammable liquid
- Vapour pressure
- Vapor pressure, kPa at 20 °C: 2.2
- Relative vapour density at 20°C
- Relative vapor density (air = 1): 4.71
- Density
- 1.04 g/cm³
- Solubility
- Solubility in water: reaction
- Log Pow
- 1.54 (calculated)
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Reacts violently with water, alcohols, and amines.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes on burning. This produces toxic and corrosive fumes. Reacts with water and moisture.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong bases, water.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled or absorbed through skin.
- Skin corrosion/irritation
- H314: Causes severe skin burns and eye damage
- Serious eye damage/irritation
- H318: Causes serious eye damage
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- H335: May cause respiratory irritation
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2742
- UN-No. (IMDG)
- UN 2742
- UN-No. (IATA)
- UN 2742
- UN-No. (ADN)
- UN 2742
- UN-No. (RID)
- UN 2742
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Isobutyl chloroformate
- Proper Shipping Name (IMDG)
- Isobutyl chloroformate
- Proper Shipping Name (IATA)
- Isobutyl chloroformate
- Proper Shipping Name (ADN)
- Isobutyl chloroformate
- Proper Shipping Name (RID)
- Isobutyl chloroformate
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1 (3,8)
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used as an activating reagent in mixed-anhydride peptide coupling reactions and ester synthesis.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2007A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 136.58 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 98.5% |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with For Synthesis grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| For Synthesis | ≥ 98% | b.p. 129 °C | ≤ 0.5% | ≤ 0.1% | None detected | Solubility in water: reaction |
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