L-Proline
- CAS Number
- 147-85-3
- HSN Code
- 29339990
- Molecular Formula
- C5H9NO2
- Catalogue Number
- AL3808
- Purity
- ≥ 99%
- Molecular Weight
- 115.13 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
L-proline is pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group.
Also known as (S)-Proline, 2-Pyrrolidinecarboxylic acid.
- Catalogue No.
- AL3808
- CAS Number
- 147-85-3
- Molecular Formula
- C5H9NO2
- Molecular Weight
- 115.13 g/mol
- HSN Code
- 29339990
- Grade
- 99%
- Product Form
- Substance
Melting point: 220-222 °C, decomposes; Density: 1.064 at 24 °C; Solubility: Solubility in 100 mL of water: 127 g at 0 °C; 162 g at 25 °C; 206.7 g at 50 °C; 239 g at 65 °C.
- Appearance
- Flat needles from alcohol + ether; prisms from water
- Shelf Life
- 2 years
- Packaging
- Available in: 5 gm glass bottle, 25 gm glass bottle, 500 gm glass bottle
- Storage
- Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.
1.1 — Product identifier
- Chemical Name
- L-Proline
- Catalogue No.
- AL3808
- Product form
- Substance
- CAS Number
- 147-85-3
- EC Number
- 205-702-2
- Grade
- 99%
- EC Index Number
- Not applicable
- Chemical Formula
- C5H9NO2
- HSN Code
- 29339990
- Synonyms
- (S)-Proline, 2-Pyrrolidinecarboxylic acid
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used in biochemistry and cell culture applications
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Not classified as hazardous (majority of notifications to the ECHA C&L Inventory)
- Classification source
- ECHA C&L Inventory via PubChem CID 145742 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- None required
- Signal word
- None
- Hazard statements
- None
2.3 — Other hazards
- Other hazards
- None known
3.1 — Substance
- Name
- L-Proline
- CAS No.
- 147-85-3
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause mild irritation to skin and eyes.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Non-flammable under normal conditions. In case of fire, use appropriate extinguishing media.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate methods. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.
8.2 — Exposure controls
- Hand protection
- Handle with gloves.
- Eye protection
- Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
- Skin and body protection
- Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
- Respiratory protection
- Not required under normal conditions of use.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odorless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 220-222 °C, decomposes
- Freezing point
- Not applicable
- Boiling point
- 300°C
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.064 at 24 °C
- Solubility
- Solubility in 100 mL of water: 127 g at 0 °C; 162 g at 25 °C; 206.7 g at 50 °C; 239 g at 65 °C
- Log Pow
- -2.54
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition it emits toxic vapors of nitrogen oxides.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Rat oral >5110 mg/kg body weight
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not classified as dangerous goods.
- UN-No. (IMDG)
- Not classified as dangerous goods.
- UN-No. (IATA)
- Not classified as dangerous goods.
- UN-No. (ADN)
- Not classified as dangerous goods.
- UN-No. (RID)
- Not classified as dangerous goods.
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not applicable
- Proper Shipping Name (IMDG)
- Not applicable
- Proper Shipping Name (IATA)
- Not applicable
- Proper Shipping Name (ADN)
- Not applicable
- Proper Shipping Name (RID)
- Not applicable
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
L-Proline is widely used in the formulation of cell-culture media, where it serves as a vital nutrient for cell growth and maintenance. In biochemistry, it is extensively utilized in research related to collagen and protein structure, aiding in the understanding of protein folding and stability. Additionally, L-Proline is employed in the pharmaceutical industry for the synthesis of various drugs and as a chiral building block in organic synthesis. Its role in metabolic pathways also makes it significant in nutritional studies and dietary supplements.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1269D
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 115.13 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | White crystalline powder | White crystalline powder |
| Assay | (Min.) 99% | 99.79% |
| Heavy metal s | <0.001% | <0.001% |
| Foreign amino acid | <0.3% | 0.2% |
| Other ninhydrin - positive substance (as glycine) | <0.1% | <0.1% |
| Ammonium (NH4) | <0.01% | <0.01% |
| Specific rotation | -84.5 to -86 o | -85 o |
The above product complies with LR grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% | ≥ 99% | m.p. 220-222 °C, decomposes | ≤ 0.5% | ≤ 0.1% | None detected | Solubility in 100 mL of water: 127 g at 0 °C; 162 g at 25 °C; 206.7 g at 50 °C; 239 g at 65 °C |
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