p-Toluenesulfonyl chloride
- CAS Number
- 98-59-9
- HSN Code
- 29041090
- Molecular Formula
- C7H7ClO2S
- Catalogue Number
- AL4608
- Purity
- ≥ 98%
- Molecular Weight
- 190.65 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
P-toluene sulfonylchloride appears as a white to gray powdered solid with a distinctive odor. Insoluble in water and denser than water.
Also known as tosyl chloride, 4-toluenesulfonyl chloride.
- Catalogue No.
- AL4608
- CAS Number
- 98-59-9
- Molecular Formula
- C7H7ClO2S
- Molecular Weight
- 190.65 g/mol
- HSN Code
- 29041090
- Grade
- 98%
- Product Form
- Substance
Melting point: 69-71 °C; Boiling point: 146 °C @ 15 MM HG; Flash point: 128 °C c.c; Density: 1.3 g/cm³; Solubility: Solubility in water: reaction.
- Appearance
- Crystals
- Shelf Life
- 2 years
- Packaging
- Available in: 500 gm plastic bottle
- Storage
- Dry. Well closed. Store in an area without drain or sewer access.
1.1 — Product identifier
- Chemical Name
- p-Toluenesulfonyl chloride
- Catalogue No.
- AL4608
- Product form
- Substance
- CAS Number
- 98-59-9
- EC Number
- 202-684-8
- Grade
- 98%
- EC Index Number
- 650-001-00-3
- Chemical Formula
- C7H7ClO2S
- HSN Code
- 29041090
- Synonyms
- tosyl chloride, 4-toluenesulfonyl chloride
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Reagent for organic synthesis, particularly in the activation of alcohols as leaving groups.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Skin Corr. 1B; Eye Dam. 1; STOT SE 3
- Classification source
- ECHA C&L Inventory via PubChem CID 7397 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Corrosive, Irritant
- Signal word
- Danger
- Hazard statements
- H314: Causes severe skin burns and eye damage; H318: Causes serious eye damage; H335: May cause respiratory irritation
2.3 — Other hazards
- Other hazards
- Corrosive to metals; may cause skin and eye burns.
3.1 — Substance
- Name
- p-Toluenesulfonyl chloride
- CAS No.
- 98-59-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with plenty of soap and water. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Burning sensation, redness, and pain in contact areas; respiratory distress if inhaled.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions; use water spray to cool containers.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into containers. Carefully collect remainder.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate PPE including gloves and goggles.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Dry. Well closed. Store in an area without drain or sewer access.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respirator if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Pungent
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- 69-71 °C
- Freezing point
- Not specified
- Boiling point
- 146 °C @ 15 MM HG
- Flash point
- 128 °C c.c.
- Auto-ignition temperature
- 492 °C
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Vapor pressure, Pa at 25 °C: 0.16
- Relative vapour density at 20°C
- Relative vapor density (air = 1): 6.6
- Density
- 1.3 g/cm³
- Solubility
- Solubility in water: reaction
- Log Pow
- 3.49
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Reacts violently with water, releasing hydrochloric acid and forming p-toluenesulfonic acid.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes on heating. This produces toxic and corrosive fumes including sulfur oxides and hydrogen chloride. Reacts with water and moist air.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Water, strong bases, and oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg; may cause burns.
- Skin corrosion/irritation
- H314: Causes severe skin burns and eye damage
- Serious eye damage/irritation
- H318: Causes serious eye damage
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- H335: May cause respiratory irritation
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3261
- UN-No. (IMDG)
- UN 3261
- UN-No. (IATA)
- UN 3261
- UN-No. (ADN)
- UN 3261
- UN-No. (RID)
- UN 3261
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (IMDG)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (IATA)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (ADN)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (RID)
- Corrosive solid, acidic, organic, n.o.s.
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
p-Toluenesulfonyl chloride is primarily used in organic synthesis as a reagent for converting alcohols into tosylate leaving groups, which enhances the reactivity of alcohols in nucleophilic substitution reactions. It is widely utilized in the pharmaceutical industry for the synthesis of various drug compounds, as well as in the production of agrochemicals and fine chemicals. Additionally, it serves as a coupling agent in peptide synthesis and is employed in the preparation of sulfonamides and other sulfonyl derivatives.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL01530
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 190.65 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 99.5% |
| Melting Point | 40-42 °C | 41 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | m.p. 69-71 °C; b.p. 146 °C @ 15 MM HG | ≤ 0.5% | ≤ 0.1% | None detected | Solubility in water: reaction |
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