Theophylline Anhydrous
- CAS Number
- 58-55-9
- HSN Code
- 29395900
- Molecular Formula
- C7H8N4O2
- Catalogue Number
- AL4526
- Purity
- 99%
- Molecular Weight
- 180.17 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.
Also known as 1,3-Dimethylxanthine.
- Catalogue No.
- AL4526
- CAS Number
- 58-55-9
- Molecular Formula
- C7H8N4O2
- Molecular Weight
- 180.17 g/mol
- HSN Code
- 29395900
- Grade
- Extra Pure
- Product Form
- Substance
Melting point: 274 °C; Density: g/cm³; Solubility: In water, 7,360 mg/L at 25 °C.
- Appearance
- White, crystalline alkaloid
- Shelf Life
- 2 years
- Packaging
- Available in: 25 gm glass bottle, 100 gm glass bottle, 500 gm glass bottle
- Storage
- Separated from food and feedstuffs.
1.1 — Product identifier
- Chemical Name
- Theophylline Anhydrous
- Catalogue No.
- AL4526
- Product form
- Substance
- CAS Number
- 58-55-9
- EC Number
- 200-385-7
- Grade
- Extra Pure
- EC Index Number
- Not applicable
- Chemical Formula
- C7H8N4O2
- HSN Code
- 29395900
- Synonyms
- 1,3-Dimethylxanthine
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Pharmaceutical reference standard, bronchodilator
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Acute Tox. 3
- Classification source
- ECHA C&L Inventory via PubChem CID 2153 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Acute Toxic
- Signal word
- Danger
- Hazard statements
- H301: Toxic if swallowed
2.3 — Other hazards
- Other hazards
- Pharmacologically active compound; handle with care.
3.1 — Substance
- Name
- Theophylline Anhydrous
- CAS No.
- 58-55-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
- First-aid measures after eye contact
- First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Nausea, vomiting, headache, insomnia, and increased heart rate may occur in case of overdose.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Combustible material; may emit toxic fumes when burned.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use personal protective equipment as required.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Separated from food and feedstuffs.
8.2 — Exposure controls
- Hand protection
- Handle with gloves.
- Eye protection
- Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odorless
- Odour threshold
- Not applicable
- pH value
- 7
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 274 °C
- Freezing point
- Not applicable
- Boiling point
- 400 °C
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- negligible
- Relative vapour density at 20°C
- Not applicable
- Density
- g/cm³
- Solubility
- In water, 7,360 mg/L at 25 °C
- Log Pow
- - 0.02
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; incompatible with strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes on heating. This produces toxic fumes including nitrogen oxides.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition it emits toxic fumes of nitrogen oxides.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Mouse oral 332 mg/kg bw; LD50 Mouse im 271 mg/kg; LD50 Mouse iv 136 mg/kg
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2811
- UN-No. (IMDG)
- UN 2811
- UN-No. (IATA)
- UN 2811
- UN-No. (ADN)
- UN 2811
- UN-No. (RID)
- UN 2811
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (IMDG)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (IATA)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (ADN)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (RID)
- Toxic solid, organic, N.O.S.
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Theophylline anhydrous is extensively used in the pharmaceutical industry as a reference standard for quality control in the development and testing of bronchodilator medications. It serves as a critical component in research studies aimed at understanding the pharmacological effects of xanthine derivatives. Additionally, it is utilized in the formulation of various therapeutic agents for respiratory diseases, contributing to the management of asthma and COPD. The compound is also employed in laboratory settings for analytical purposes, including high-performance liquid chromatography (HPLC) and other analytical techniques.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2567J
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 180.17 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | White crystalline powder | White crystalline powder |
| Assay | Min. 99.0% | 99.22% |
| Melting point | 271 - 273°C | 273°C |
| Loss on Drying | <0.5% | 0.3% |
The above product complies with EP grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | 99% | m.p. 274 °C | <0.5% | <0.1% | None detected | In water, 7,360 mg/L at 25 °C |
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