Trimethyl Phosphite
- CAS Number
- 121-45-9
- HSN Code
- 29202300
- Molecular Formula
- C3H9O3P
- Catalogue Number
- AL4676
- Purity
- ≥ 98%
- Molecular Weight
- 124.08 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds.
Also known as Trimethyl phosphite, Phosphorous acid trimethyl ester.
- Catalogue No.
- AL4676
- CAS Number
- 121-45-9
- Molecular Formula
- C3H9O3P
- Molecular Weight
- 124.08 g/mol
- HSN Code
- 29202300
- Grade
- 98%
- Product Form
- Substance
Melting point: -78 °C; Boiling point: 110 °C; Flash point: 28 °C (82 °F) - closed cup; Density: 1.0518 g/cu cm at 20 °C; Solubility: Reacts (hydrolyzes) with water.
- Appearance
- Colorless liquid
- Shelf Life
- 2 years
- Packaging
- Available in: 250 ml glass bottle, 1 Lt glass bottle
- Storage
- Fireproof. Separated from oxidants and strong bases.
1.1 — Product identifier
- Chemical Name
- Trimethyl Phosphite
- Catalogue No.
- AL4676
- Product form
- Substance
- CAS Number
- 121-45-9
- EC Number
- 204-471-5
- Grade
- 98%
- EC Index Number
- phosphonic acid esters
- Chemical Formula
- C3H9O3P
- HSN Code
- 29202300
- Synonyms
- Trimethyl phosphite, Phosphorous acid trimethyl ester
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used as a reagent in organic synthesis, particularly in the production of phosphonate esters.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; STOT SE 3
- Classification source
- ECHA C&L Inventory via PubChem CID 8472 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Flammable, Corrosive, Irritant
- Signal word
- Danger
- Hazard statements
- H226: Flammable liquid and vapor; H302: Harmful if swallowed; H315: Causes skin irritation; H318: Causes serious eye damage; H335: May cause respiratory irritation
2.3 — Other hazards
- Other hazards
- May cause respiratory irritation; vapors may be harmful.
3.1 — Substance
- Name
- Trimethyl Phosphite
- CAS No.
- 121-45-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
- First-aid measures after skin contact
- If this chemical contacts the skin, immediately flush the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention.
- First-aid measures after eye contact
- If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
- First-aid measures after ingestion
- If this chemical has been swallowed, get medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of the eyes, skin, and respiratory tract; headache; dizziness.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Dry powder.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Flammable liquid; may produce toxic fumes in a fire.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Use appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Personal protection: self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area and avoid inhalation of vapors.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Fireproof. Separated from oxidants and strong bases.
8.2 — Exposure controls
- Hand protection
- Handle with gloves.
- Eye protection
- Tightly fitting safety goggles. Faceshield (8-inch minimum).
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Irritating, pungent, oily, pyridine-like odor
- Odour threshold
- No data available
- pH value
- No data available
- Relative evaporation rate (butylacetate=1)
- No data available
- Melting point
- -78 °C
- Freezing point
- No data available
- Boiling point
- 110 °C
- Flash point
- 28 °C (82 °F) - closed cup
- Auto-ignition temperature
- 250 °C
- Decomposition temperature
- No data available
- Flammability (solid, gas)
- Flammable liquid
- Vapour pressure
- Vapor pressure = 24 torr at 25 °C (saturates in air at 32,000 ppm)
- Relative vapour density at 20°C
- 4.3 (Air = 1)
- Density
- 1.0518 g/cu cm at 20 °C
- Solubility
- Reacts (hydrolyzes) with water
- Log Pow
- No data available
- Viscosity, kinematic
- No data available
- Viscosity, dynamic
- 1.2 mPa·s at 20°C
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- No data available
10.1 — Reactivity
- Reactivity
- Reacts with strong oxidizing agents and bases.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- On combustion, forms toxic fumes including phosphine and phosphorus oxides. Reacts with water. This produces methanol and dimethyl phosphite.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizers, strong bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Hazardous decomposition products formed under fire conditions - Carbon oxides, oxides of phosphorus.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Rat oral 2500-2890 mg/kg; LD50 Rat oral 1600 mg/kg; LD50 Rabbit dermal 2600 mg/kg
- Skin corrosion/irritation
- H315: Causes skin irritation
- Serious eye damage/irritation
- H318: Causes serious eye damage
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- H335: May cause respiratory irritation
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2329
- UN-No. (IMDG)
- UN 2329
- UN-No. (IATA)
- UN 2329
- UN-No. (ADN)
- UN 2329
- UN-No. (RID)
- UN 2329
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Trimethyl phosphite
- Proper Shipping Name (IMDG)
- Trimethyl phosphite
- Proper Shipping Name (IATA)
- Trimethyl phosphite
- Proper Shipping Name (ADN)
- Trimethyl phosphite
- Proper Shipping Name (RID)
- Trimethyl phosphite
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Trimethyl phosphite is primarily used as a reagent in the Michaelis-Arbuzov reaction, which is essential for synthesizing phosphonate esters in organophosphorus chemistry. This compound is also utilized in the production of flame retardants, plasticizers, and agricultural chemicals. In the pharmaceutical industry, it serves as an intermediate in the synthesis of various bioactive compounds. Additionally, trimethyl phosphite is employed in the preparation of organophosphorus ligands for catalysis and in the development of new materials with specific chemical properties.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2582E
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 124.08 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 98.5% |
| Density | 1.052 g/mL | 1.052 g/mL |
| Boiling Point | 165°C | 165°C |
| Flash Point | 40°C | 40°C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | m.p. -78 °C; b.p. 110 °C | ≤ 0.5% | ≤ 0.1% | None detected | Reacts (hydrolyzes) with water |
Related Products
View AllWhy buy from Alpha Chemika
What Our Scientific & Industrial Customers Say
“Speedy delivery, professional staff.”
“One shop stop for all laboratory chemicals requirements.”
“Exactly as advertised.”
“Alpha Chemika products are of excellent quality. Highly satisfied.”
“From ordering to shipping, every course of action was smooth. Timely delivery.”
“Completely satisfied with the products and services.”
“Speedy delivery, professional staff.”
“One shop stop for all laboratory chemicals requirements.”
“Exactly as advertised.”
“One shop stop for all laboratory chemicals requirements.”
“Exactly as advertised.”
“Alpha Chemika products are of excellent quality. Highly satisfied.”
“Exactly as advertised.”
“Alpha Chemika products are of excellent quality. Highly satisfied.”
“From ordering to shipping, every course of action was smooth. Timely delivery.”
“Alpha Chemika products are of excellent quality. Highly satisfied.”
“From ordering to shipping, every course of action was smooth. Timely delivery.”
“Completely satisfied with the products and services.”
“From ordering to shipping, every course of action was smooth. Timely delivery.”
“Completely satisfied with the products and services.”
“Speedy delivery, professional staff.”
“Completely satisfied with the products and services.”
“Speedy delivery, professional staff.”
“One shop stop for all laboratory chemicals requirements.”
FAQs
Common Questions About Laboratory Chemicals & Solutions
Find answers to common questions about laboratory chemicals, product selection, documentation, ordering, and technical support. Whether you are sourcing chemicals for research, testing, education, manufacturing, or industrial applications, these FAQs can help you make informed purchasing decisions.
Alpha Chemika offers a wide range of laboratory chemicals, reagents, solvents, and specialty products for research, testing, educational, pharmaceutical, and industrial applications.
Product selection depends on factors such as application, required purity, grade, specifications, and intended use. Our team can help you identify suitable products based on your technical requirements.
Yes. Relevant product information and technical documentation can be provided to help you evaluate products for quality, handling, compliance, and application requirements.
Yes. You can share your product list, required quantities, specifications, and delivery requirements with our team for a tailored quotation.
Yes. We support requirements from research laboratories, educational institutions, pharmaceutical companies, manufacturers, distributors, and other scientific and industrial organizations.
Connect with Us for Your Requirements
Have a specific product requirement or need help finding the right chemical for your application? Share your requirements with our team, and we will help you identify suitable products, specifications, quantities, and procurement options.
