Acetone cyanohydrin
- CAS Number
- 75-86-5
- HSN Code
- 29269000
- Molecular Formula
- C4H7NO
- Catalogue Number
- AL0066
- Purity
- ≥ 98.5%
- Molecular Weight
- 85.10 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
2-hydroxy-2-methylpropanenitrile is a cyanohydrin.
Also known as 2-Hydroxy-2-methylpropanenitrile.
- Catalogue No.
- AL0066
- CAS Number
- 75-86-5
- Molecular Formula
- C4H7NO
- Molecular Weight
- 85.10 g/mol
- HSN Code
- 29269000
- Grade
- 98.5% For Synthesis
- Product Form
- Substance
Melting point: -19 °C; Boiling point: 95 °C; Flash point: 165 °F (74 °C) (closed cup); Density: Specific gravity: 0.9267 at 25 °C/4 °C; Solubility: Freely soluble in usual organic solvents; insoluble in petroleum ether and carbon disulfide.
- Appearance
- Colorless liquid
- Shelf Life
- -
- Packaging
- Available in: 100 ml glass bottle with tin cap
- Storage
- Provision to contain effluent from fire extinguishing. Separated from strong bases, acids, water and food and feedstuffs. Well closed. Keep in a well-ventilated room.
1.1 — Product identifier
- Chemical Name
- Acetone cyanohydrin
- Catalogue No.
- AL0066
- Product form
- Substance
- CAS Number
- 75-86-5
- EC Number
- 200-909-4
- Grade
- 98.5% For Synthesis
- EC Index Number
- 607-001-00-0
- Chemical Formula
- C4H7NO
- HSN Code
- 29269000
- Synonyms
- 2-Hydroxy-2-methylpropanenitrile
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used as a precursor in organic synthesis and as a controlled HCN-releasing reagent.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Acute Tox. 2; Acute Tox. 1; Aquatic Acute 1; Aquatic Chronic 1
- Classification source
- ECHA C&L Inventory via PubChem CID 6406 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Acute Toxic, Environmental Hazard
- Signal word
- Danger
- Hazard statements
- H300: Fatal if swallowed; H310: Fatal in contact with skin; H330: Fatal if inhaled; H400: Very toxic to aquatic life; H410: Very toxic to aquatic life with long lasting effects
2.3 — Other hazards
- Other hazards
- Releases hydrogen cyanide upon decomposition; highly toxic.
3.1 — Substance
- Name
- Acetone cyanohydrin
- CAS No.
- 75-86-5
4.1 — Description of first aid measures
- First-aid measures after inhalation
- If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
- First-aid measures after skin contact
- If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.
- First-aid measures after eye contact
- If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
- First-aid measures after ingestion
- If this chemical has been swallowed, get medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, respiratory distress, and potential cyanide poisoning symptoms.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- The vapour is heavier than air.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Wear appropriate protective equipment. Contain and neutralize spill with sodium bicarbonate or lime.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate PPE. Avoid contact with skin and eyes.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Provision to contain effluent from fire extinguishing. Separated from strong bases, acids, water and food and feedstuffs. Well closed. Keep in a well-ventilated room.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use a NIOSH-approved respirator if exposure limits are exceeded.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Distinct strong cyanide odor
- Odour threshold
- Not specified
- pH value
- Not specified
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -19 °C
- Freezing point
- Not specified
- Boiling point
- 95 °C
- Flash point
- 165 °F (74 °C) (closed cup)
- Auto-ignition temperature
- 1270 °F (688 °C)
- Decomposition temperature
- Decomposes at elevated temperatures, releasing HCN
- Flammability (solid, gas)
- Not applicable
- Vapour pressure
- Vapor pressure = 0.8 mm Hg at 20 °C
- Relative vapour density at 20°C
- 2.96 (Air = 1)
- Density
- Specific gravity: 0.9267 at 25 °C/4 °C
- Solubility
- Freely soluble in usual organic solvents; insoluble in petroleum ether and carbon disulfide.
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive under normal conditions
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; reacts with strong acids and bases.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes rapidly on heating and on contact with bases and water. This produces highly toxic and flammable hydrogen cyanide (see ICSC 0492) and acetone (see ICSC 0087). Reacts violently with acids and oxidants.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizers, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition it emits toxic fumes of hydrogen cyanide.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 Rat oral 0.17 g/kg; LD50 Rat oral 19,300 ug/kg; LD50 Mouse oral 15 mg/kg.
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- Not classified (based on available data)
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 1541
- UN-No. (IMDG)
- UN 1541
- UN-No. (IATA)
- UN 1541
- UN-No. (ADN)
- UN 1541
- UN-No. (RID)
- UN 1541
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Acetone cyanohydrin
- Proper Shipping Name (IMDG)
- Acetone cyanohydrin
- Proper Shipping Name (IATA)
- Acetone cyanohydrin
- Proper Shipping Name (ADN)
- Acetone cyanohydrin
- Proper Shipping Name (RID)
- Acetone cyanohydrin
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1
14.4 — Packing group
- Packing group (ADR)
- I
- Packing group (IMDG)
- I
- Packing group (IATA)
- I
- Packing group (ADN)
- I
- Packing group (RID)
- I
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used as a precursor in the synthesis of methyl methacrylate and as a controlled HCN-releasing synthesis reagent.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL01667
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 85.10 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98.5% | 99.0% |
| Density | 0.932 g/mL | 0.932 g/mL |
| Boiling Point | 90 °C | 90 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Related Substances | Not specified | None detected |
The above product is expected to comply with 98.5% For Synthesis grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98.5% For Synthesis | ≥ 98.5% | m.p. -19 °C; b.p. 95 °C | ≤ 0.5% | Not specified | Not specified | Freely soluble in usual organic solvents; insoluble in petroleum ether and carbon disulfide. |
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