Brucine

1.1 — Product identifier

Chemical Name

Brucine

Catalogue No.

AL0904

Product form

Substance

CAS Number

357-57-3

EC Number

206-614-7

Grade

AR (Analytical Reagent)

EC Index Number

N/A

Chemical Formula

C23H26N2O4

HSN Code

29397900

Synonyms

Brucina

1.2 — Relevant identified uses of the substance or mixture and uses advised against

Use of the substance/mixture

Chiral resolving agent in asymmetric synthesis

Uses advised against

Not specified

1.3 — Details of the supplier of the safety data sheet

Company identification

Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.

1.4 — Emergency Contact Details

Phone / e-Mail

Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in

2.1 — Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008

Acute Tox. 2; Aquatic Chronic 3

Classification source

ECHA C&L Inventory via PubChem CID 442021 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements

2.2 — Label elements

Hazard pictograms

Acute Toxic

Signal word

Danger

Hazard statements

H300: Fatal if swallowed; H330: Fatal if inhaled; H412: Harmful to aquatic life with long lasting effects

2.3 — Other hazards

Other hazards

None identified

3.1 — Substance

Name

Brucine

CAS No.

357-57-3

4.1 — Description of first aid measures

First-aid measures after inhalation

Move to fresh air. Seek medical attention if symptoms persist.

First-aid measures after skin contact

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.

First-aid measures after eye contact

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.

First-aid measures after ingestion

Do not induce vomiting. Rinse mouth and seek medical attention immediately.

4.2 — Most important symptoms and effects, both acute and delayed

Symptoms relating to use

Nausea, vomiting, abdominal pain, dizziness, and respiratory distress.

4.3 — Indication of any immediate medical attention and special treatment needed

General information

Treat symptomatically. Show this safety data sheet to the treating physician.

5.1 — Extinguishing media

Suitable extinguishing media

Water spray, carbon dioxide, dry chemical powder, foam.

Unsuitable extinguishing media

Not specified

5.2 — Special hazards arising from the substance or mixture

Special procedures

Toxic fumes may be released in a fire.

5.3 — Advice for firefighters

Protection during firefighting

Do not enter fire area without proper protective equipment, including respiratory protection.

6.1.1 — For non-emergency personnel

Emergency procedures

Evacuate area and ventilate. Wear appropriate protective equipment.

6.3 — Methods and material for containment and cleaning up

Methods for cleaning up

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

6.4 — Reference to other sections

Reference

Not specified

7.1 — Precautions for safe handling

Precautions for safe handling

Use personal protective equipment. Avoid contact with skin and eyes. Do not breathe dust.

Hygiene measures

Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.

7.2 — Conditions for safe storage, including any incompatibilities

Storage conditions

Separated from strong oxidants and food and feedstuffs. Dry. Well closed.

8.2 — Exposure controls

Hand protection

Protective gloves (e.g. nitrile rubber)

Eye protection

Chemical safety goggles or safety glasses

Skin and body protection

Wear suitable protective clothing

Respiratory protection

Use appropriate respiratory protection if dust is generated.

9.1 — Information on basic physical and chemical properties

Physical state

Solid

Colour

White to pale yellow

Odour

Odorless

Odour threshold

Not applicable

pH value

Not applicable

Relative evaporation rate (butylacetate=1)

Not applicable

Melting point

178 °C

Freezing point

Not applicable

Boiling point

470 °C

Flash point

Not applicable

Auto-ignition temperature

Not applicable

Decomposition temperature

Not applicable

Flammability (solid, gas)

Not flammable

Vapour pressure

Not applicable

Relative vapour density at 20°C

Not applicable

Density

greater than 1 at 68 °F

Solubility

Crystals. Sol in water or alcohol. The solns are neutral or slightly acid.

Log Pow

Log Kow= 0.98

Viscosity, kinematic

Not applicable

Viscosity, dynamic

Not applicable

Explosive properties

Not explosive

Oxidising properties

Not oxidising

Explosive limits

Not applicable

10.1 — Reactivity

Reactivity

Stable under recommended storage conditions.

10.2 — Chemical stability

Chemical stability

Stable during transport.

10.3 — Possibility of hazardous reactions

Possibility of hazardous reactions

Decomposes on heating. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base.

10.4 — Conditions to avoid

Conditions to avoid

Avoid contact with incompatible materials and excessive heat.

10.5 — Incompatible materials

Incompatible materials

Strong oxidizing agents.

10.6 — Hazardous decomposition products

Hazardous decomposition products

When heated to decomposition it emits toxic fumes of nitroxides.

11.1 — Information on toxicological effects

Acute toxicity

LD50 Rabbit oral 4 mg/kg; LD50 Rat ip 91 mg/kg; LD50 Mouse sc 60 mg/kg

Skin corrosion/irritation

Not classified (based on available data)

Serious eye damage/irritation

Not classified (based on available data)

Respiratory or skin sensitisation

Not classified (based on available data)

Germ cell mutagenicity

Not classified (based on available data)

Carcinogenicity

Not classified (based on available data)

Specific target organ toxicity (single exposure)

Not classified (based on available data)

Specific target organ toxicity (repeated exposure)

Not classified (based on available data)

12.1 — Toxicity

Toxicity information

Not specified

12.2 — Persistence - degradability

Persistence - degradability

Not specified

12.3 — Bioaccumulative potential

Bioaccumulative potential

Not specified

12.4 — Mobility in soil

Mobility in soil

Not specified

12.6 — Other adverse effects

Environmental precautions

Not specified

13.1 — Waste treatment methods

Additional Info

Dispose of contents/container in accordance with local, regional, national and international regulations.

14.1 — UN number

UN-No. (ADR)

UN 1570

UN-No. (IMDG)

UN 1570

UN-No. (IATA)

UN 1570

UN-No. (ADN)

UN 1570

UN-No. (RID)

UN 1570

14.2 — UN proper shipping name

Proper Shipping Name (ADR)

Brucine

Proper Shipping Name (IMDG)

Brucine

Proper Shipping Name (IATA)

Brucine

Proper Shipping Name (ADN)

Brucine

Proper Shipping Name (RID)

Brucine

14.3 — Transport hazard class(es)

Transport hazard class(es)

6.1

14.4 — Packing group

Packing group (ADR)

I

Packing group (IMDG)

I

Packing group (IATA)

I

Packing group (ADN)

I

Packing group (RID)

I

14.5 — Environmental hazards

Dangerous for the environment

Not specified

Marine pollutant

Not specified

Other information

No supplementary information available

15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture

15.1.1 EU-Regulations

Not specified