Dimethyl sulfate
- CAS Number
- 77-78-1
- HSN Code
- 29209099
- Molecular Formula
- (CH3O)2SO2
- Catalogue Number
- AL1874
- Purity
- ≥ 99%
- Molecular Weight
- 126.13 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Dimethyl sulfate is the dimethyl ester of sulfuric acid. It has a role as an alkylating agent and an immunosuppressive agent.
Also known as Methyl sulfate, Dimethylsulfate.
- Catalogue No.
- AL1874
- CAS Number
- 77-78-1
- Molecular Formula
- (CH3O)2SO2
- Molecular Weight
- 126.13 g/mol
- HSN Code
- 29209099
- Grade
- 99% For Synthesis
- Product Form
- Substance
Melting point: -27 °C; Boiling point: About 188 °C with decomposition; Flash point: 182 °F (83 °C) (open cup); Density: 1.3322 gcu cm at 20 °C4 °C; Solubility: Sol in ether, dioxane, acetone, aromatic hydrocarbons.
- Appearance
- Colorless oily liquid
- Shelf Life
- -
- Packaging
- Available in: 500 ml glass bottle with tin cap, 2.5 Lt glass bottle with tin cap
- Storage
- Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access.
1.1 — Product identifier
- Chemical Name
- Dimethyl sulfate
- Catalogue No.
- AL1874
- Product form
- Substance
- CAS Number
- 77-78-1
- EC Number
- 201-058-1
- Grade
- 99% For Synthesis
- EC Index Number
- Not specified
- Chemical Formula
- (CH3O)2SO2
- HSN Code
- 29209099
- Synonyms
- Methyl sulfate, Dimethylsulfate
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Methylating agent in organic synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1; Acute Tox. 2; STOT SE 3; Muta. 2; Carc. 1B
- Classification source
- ECHA C&L Inventory via PubChem CID 6497 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Corrosive, Acute Toxic, Health Hazard
- Signal word
- Danger
- Hazard statements
- H301: Toxic if swallowed; H314: Causes severe skin burns and eye damage; H317: May cause an allergic skin reaction; H330: Fatal if inhaled; H335: May cause respiratory irritation; H341: Suspected of causing genetic defects; H350: May cause cancer
2.3 — Other hazards
- Other hazards
- Corrosive to metals, may cause severe burns.
3.1 — Substance
- Name
- Dimethyl sulfate
- CAS No.
- 77-78-1
4.1 — Description of first aid measures
- First-aid measures after inhalation
- If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
- First-aid measures after skin contact
- If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.
- First-aid measures after eye contact
- If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
- First-aid measures after ingestion
- If this chemical has been swallowed, get medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Coughing, shortness of breath, skin burns, eye irritation.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions. Use water spray to cool containers.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Wear appropriate protective equipment. Contain and absorb spill with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use only in a fume hood with appropriate PPE. Avoid contact with skin and eyes.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use a NIOSH-approved respirator if exposure limits are exceeded.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Essentially odorless
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -27 °C
- Freezing point
- Not specified
- Boiling point
- About 188 °C with decomposition
- Flash point
- 182 °F (83 °C) (open cup)
- Auto-ignition temperature
- 370 °F (188 °C)
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- 0.677 mm Hg at 25 °C
- Relative vapour density at 20°C
- 4.35 (Air = 1)
- Density
- 1.3322 gcu cm at 20 °C4 °C
- Solubility
- Sol in ether, dioxane, acetone, aromatic hydrocarbons.
- Log Pow
- 0.16
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Reacts violently with strong bases and nucleophiles.
10.2 — Chemical stability
- Chemical stability
- Stable at room temperature.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- Decomposes on heating and on burning. This produces toxic fumes including sulfur oxides. The solution is a medium strong acid.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong bases, strong oxidizers, amines, and alcohols.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LC50 Guinea pig inhalation 167 mgcu m (32 ppm)60 min.; LC50 Mouse inhalation 513 mgcu m (98 ppm)60 min.; LC50 Mouse inhalation 280 mgcu m4 hr.
- Skin corrosion/irritation
- H314: Causes severe skin burns and eye damage
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- H317: May cause an allergic skin reaction
- Germ cell mutagenicity
- H341: Suspected of causing genetic defects
- Carcinogenicity
- H350: May cause cancer
- Specific target organ toxicity (single exposure)
- H335: May cause respiratory irritation
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 1595
- UN-No. (IMDG)
- UN 1595
- UN-No. (IATA)
- UN 1595
- UN-No. (ADN)
- UN 1595
- UN-No. (RID)
- UN 1595
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Dimethyl sulfate
- Proper Shipping Name (IMDG)
- Dimethyl sulfate
- Proper Shipping Name (IATA)
- Dimethyl sulfate
- Proper Shipping Name (ADN)
- Dimethyl sulfate
- Proper Shipping Name (RID)
- Dimethyl sulfate
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1 (8)
14.4 — Packing group
- Packing group (ADR)
- I
- Packing group (IMDG)
- I
- Packing group (IATA)
- I
- Packing group (ADN)
- I
- Packing group (RID)
- I
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used as a methylating reagent in dye, pharmaceutical, and agrochemical synthesis, subject to strict handling and exposure controls.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL00635
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 126.13 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | Almost clear colourless liquid | Almost clear colourless liquid |
| Assay | (Min.) 99% | 99.25% |
The above product complies with LR grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% For Synthesis | ≥ 99% | m.p. -27 °C; b.p. About 188 °C with decomposition | ≤ 0.5% | ≤ 0.1% | None detected | Sol in ether, dioxane, acetone, aromatic hydrocarbons. |
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