Progesterone
- CAS Number
- 57-83-0
- HSN Code
- 29372300
- Molecular Formula
- C21H30O2
- Catalogue Number
- AL3806
- Purity
- 97% min
- Molecular Weight
- 314.46 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Also known as Pregn-4-ene-3,20-dione; 17-Hydroxyprogesterone; 4-Pregnen-3,20-dione.
- Catalogue No.
- AL3806
- CAS Number
- 57-83-0
- Molecular Formula
- C21H30O2
- Molecular Weight
- 314.46 g/mol
- HSN Code
- 29372300
- Grade
- 97%
- Product Form
- Substance
Melting point: 129 °C; Density: 1.166 g/cu cm at 23 °C; Solubility: Sol in alcohol, acetone, dioxane beta-Progesterone.
- Appearance
- Prisms
- Shelf Life
- 2 years
- Packaging
- Available in: 5 gm glass bottle
- Storage
- Parenteral progesterone preparations, progesterone capsules, progesterone vaginal inserts, and progesterone vaginal gel should be stored at 15-30 °C.
1.1 — Product identifier
- Chemical Name
- Progesterone
- Catalogue No.
- AL3806
- Product form
- Substance
- CAS Number
- 57-83-0
- EC Number
- 200-350-6
- Grade
- 97%
- EC Index Number
- 607-003-00-4
- Chemical Formula
- C21H30O2
- HSN Code
- 29372300
- Synonyms
- Pregn-4-ene-3,20-dione; 17-Hydroxyprogesterone; 4-Pregnen-3,20-dione
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used in biochemistry and pharmaceutical applications as a hormone standard.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Carc. 2; Repr. 1B; Lact.
- Classification source
- ECHA C&L Inventory via PubChem CID 5994 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Health Hazard
- Signal word
- Danger
- Hazard statements
- H351: Suspected of causing cancer; H360: May damage fertility or the unborn child; H362: May cause harm to breast-fed children
2.3 — Other hazards
- Other hazards
- None identified; handle with care as it is a pharmacologically active compound.
3.1 — Substance
- Name
- Progesterone
- CAS No.
- 57-83-0
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water.
- First-aid measures after eye contact
- First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause skin irritation or allergic reactions in sensitive individuals.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Combustible material; may produce toxic fumes when burned.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use gloves and protective eyewear when handling.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Parenteral progesterone preparations, progesterone capsules, progesterone vaginal inserts, and progesterone vaginal gel should be stored at 15-30 °C.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Not required under normal conditions; use in well-ventilated areas.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odorless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 129 °C
- Freezing point
- Not applicable
- Boiling point
- 330 °C
- Flash point
- 150 °C
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Combustible solid
- Vapour pressure
- <0.01 mmHg at 25 °C
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.166 g/cu cm at 23 °C
- Solubility
- Sol in alcohol, acetone, dioxane beta-Progesterone
- Log Pow
- 3.87
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Progesterone is stable when exposed to air. The drug should be stored in tight, light-resistant containers.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition, it emits acrid smoke and irritating fumes.
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg; low toxicity.
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- Not classified (based on available data)
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- H351: Suspected of causing cancer
- Specific target organ toxicity (single exposure)
- Not classified (based on available data)
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not classified as dangerous goods.
- UN-No. (IMDG)
- Not classified as dangerous goods.
- UN-No. (IATA)
- Not classified as dangerous goods.
- UN-No. (ADN)
- Not classified as dangerous goods.
- UN-No. (RID)
- Not classified as dangerous goods.
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Progesterone
- Proper Shipping Name (IMDG)
- Progesterone
- Proper Shipping Name (IATA)
- Progesterone
- Proper Shipping Name (ADN)
- Progesterone
- Proper Shipping Name (RID)
- Progesterone
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Progesterone is widely used as a reference standard in pharmaceutical hormone quality control, ensuring the accuracy and reliability of hormone assays. It is also utilized in endocrinology and reproductive biology research to study hormonal effects on the menstrual cycle, pregnancy, and embryonic development. Additionally, progesterone is employed in the formulation of hormone replacement therapies and contraceptives, making it significant in both clinical and research settings.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2485D
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 314.46 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 97% min | 97.5% |
| Melting Point | 124-127 °C | 125 °C |
| Moisture Content | <0.5% | 0.3% |
| Residue on Ignition | <0.1% | 0.05% |
| Related Substances | <1% | 0.8% |
The above product is expected to comply with 97% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 97% | 97% min | m.p. 129 °C | <0.5% | <0.1% | <1% | Sol in alcohol, acetone, dioxane beta-Progesterone |
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