Tetrahydrofuran
- CAS Number
- 109-99-9
- HSN Code
- 29321100
- Molecular Formula
- C4H8O
- Catalogue Number
- AL4493
- Purity
- 99.8%
- Molecular Weight
- 72.11 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Oxolane is a cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen. It has a role as a polar aprotic solvent.
Also known as THF, 1,4-Butyrolactone.
- Catalogue No.
- AL4493
- CAS Number
- 109-99-9
- Molecular Formula
- C4H8O
- Molecular Weight
- 72.11 g/mol
- HSN Code
- 29321100
- Grade
- HPLC & Spectroscopy
- Product Form
- Substance
Melting point: -108.44 °C; Boiling point: 65 °C; Flash point: -14 °C; Density: 0.8833 g/cu cm at 25 °C; Solubility: Miscible with alcohols, ketones, esters, hydrocarbons, and ethers.
- Appearance
- Colorless, mobile liquid
- Shelf Life
- 12 months
- Packaging
- Available in: 500 ml glass bottle, 1 Lt glass bottle with tin cap, 2.5 Lt glass bottle with tin cap
- Storage
- Fireproof. Well closed. Keep separated from incompatible materials.
1.1 — Product identifier
- Chemical Name
- Tetrahydrofuran
- Catalogue No.
- AL4493
- Product form
- Substance
- CAS Number
- 109-99-9
- EC Number
- 203-726-8
- Grade
- HPLC & Spectroscopy
- EC Index Number
- 607-195-00-7
- Chemical Formula
- C4H8O
- HSN Code
- 29321100
- Synonyms
- THF, 1,4-Butyrolactone
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Solvent for chromatography and spectroscopy
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.1 — Classification of the substance or mixture
- Classification according to Regulation (EC) No 1272/2008
- Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; Carc. 2
- Classification source
- ECHA C&L Inventory via PubChem CID 8028 - hazard classes notified by at least 50% of companies; pictograms and signal word derived from those statements
2.2 — Label elements
- Hazard pictograms
- Flammable, Irritant, Health Hazard
- Signal word
- Danger
- Hazard statements
- H225: Highly Flammable liquid and vapor; H319: Causes serious eye irritation; H335: May cause respiratory irritation; H351: Suspected of causing cancer
2.3 — Other hazards
- Other hazards
- Forms explosive peroxides upon prolonged exposure to air and light.
3.1 — Substance
- Name
- Tetrahydrofuran
- CAS No.
- 109-99-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- If this chemical has been inhaled, remove the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the person warm and at rest.
- First-aid measures after skin contact
- If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.
- First-aid measures after eye contact
- If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
- First-aid measures after ingestion
- If this chemical has been swallowed, get medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, respiratory irritation, skin irritation.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Tetrahydrofuran (THF) is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." A 5% solution of THF in water is flammable.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Remove all sources of ignition. Ventilate area.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Do NOT wash away into sewer.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a well-ventilated area. Avoid contact with skin and eyes. Keep away from heat and ignition sources.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Fireproof. Well closed. Keep separated from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Ether-like odor
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- >1
- Melting point
- -108.44 °C
- Freezing point
- Not specified
- Boiling point
- 65 °C
- Flash point
- -14 °C
- Auto-ignition temperature
- 321 °C (610 °F)
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Highly flammable liquid
- Vapour pressure
- Vapor pressure = 0.06 atm at 0 °C, 0.11 atm at 10 °C, 0.173 atm at 20 °C, 0.26 atm at 30 °C
- Relative vapour density at 20°C
- 2.5 (Air = 1)
- Density
- 0.8833 g/cu cm at 25 °C
- Solubility
- Miscible with alcohols, ketones, esters, hydrocarbons, and ethers.
- Log Pow
- 0.46
- Viscosity, kinematic
- 0.45 cSt at 20°C
- Viscosity, dynamic
- Not specified
- Explosive properties
- Forms explosive peroxides
- Oxidising properties
- Not oxidizing
- Explosive limits
- 1.8 - 11.8% (v/v) in air
10.1 — Reactivity
- Reactivity
- Reacts violently with strong oxidizers and can form peroxides upon exposure to air.
10.2 — Chemical stability
- Chemical stability
- Tetrahydrofuran will auto-oxidize in the presence of light & O2 to form resinous products that color water from pink to brown at conc above 100-250 mg/l.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- The substance can form explosive peroxides. Reacts violently with strong oxidants, strong bases and some metal halides. This generates fire and explosion hazard.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- When heated to decomposition it emits acrid smoke & irritating fumes.
11.1 — Information on toxicological effects
- Acute toxicity
- LC50 Rat inhalation 80,975 ppm/1 hr; LC50 Rat inhalation 62,000 ppm/2 hr; LC50 Rat inhalation 18,000-22,000 ppm/4 hr
- Skin corrosion/irritation
- Not classified (based on available data)
- Serious eye damage/irritation
- H319: Causes serious eye irritation
- Respiratory or skin sensitisation
- Not classified (based on available data)
- Germ cell mutagenicity
- Not classified (based on available data)
- Carcinogenicity
- H351: Suspected of causing cancer
- Specific target organ toxicity (single exposure)
- H335: May cause respiratory irritation
- Specific target organ toxicity (repeated exposure)
- Not classified (based on available data)
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- 2056
- UN-No. (IMDG)
- 2056
- UN-No. (IATA)
- 2056
- UN-No. (ADN)
- 2056
- UN-No. (RID)
- 2056
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Tetrahydrofuran
- Proper Shipping Name (IMDG)
- Tetrahydrofuran
- Proper Shipping Name (IATA)
- Tetrahydrofuran
- Proper Shipping Name (ADN)
- Tetrahydrofuran
- Proper Shipping Name (RID)
- Tetrahydrofuran
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Tetrahydrofuran is primarily used as a solvent in chromatographic techniques, particularly as a mobile-phase solvent in gel permeation chromatography (GPC) and size exclusion chromatography (SEC) for polymer molecular-weight analysis. It is also utilized in the synthesis of polymers, pharmaceuticals, and as a solvent for various chemical reactions. Additionally, THF serves as a reagent in the production of tetrahydrofuran-based polymers and is used in the formulation of coatings, adhesives, and sealants in the chemical industry.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL02566
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 72.11 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99.8% min | 99.85% |
| Water Content | <0.1% | 0.05% |
| Residue on Ignition | <0.01% | 0.005% |
| Related Substances | <0.1% | 0.03% |
| Appearance | Colorless liquid | Colorless liquid |
The above product is expected to comply with HPLC & Spectroscopy grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| HPLC & Spectroscopy | 99.8% | m.p. -108.44 °C; b.p. 65 °C | <0.1% | <0.01% | <0.1% | Miscible with alcohols, ketones, esters, hydrocarbons, and ethers. |
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